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农业表观基因组学创新团队

来源: 发布者: 时间:2019年03月02日

农业表观基因组学创新团队

创新团队首席科学家:高飞

研究方向:

团队从表观基因组学角度出发,开展以下三方面的工作:描绘动植物发育过程中表观基因组景观、开发表观基因组学新方法、研究动植物基因组与环境因子互作的表观遗传调控机制。

主要研究成果:

运用针对微量细胞的全基因组甲基化测序技术,团队首次揭示了灵长类哺乳动物早期胚胎发育的精细DNA甲基化图谱表观遗传学调控机制;与哥本哈根大学紧密合作,运用多组学手段论证了营养、抗生素(肠道菌群)对仔猪肠道DNA甲基化及仔猪肠组织免疫与代谢功能基因的影响。先后在Cell Research、Genome Biology、DNA Research等国际期刊发表一系列成果。

Agricultural Epigenomics Group (AEG)

Chief scientist:Fei Gao

Research Field:

Applying omics-based methodology, AEG team focus on three categories of researches:1) deciphering epigenome landscape during the development of animals and plants, 2) developing new methodologies of epigenomics and 3) studying epigenomic regulation of the interaction between genomes and environmental factors.

Achievements:

Using a novel whole-genome bisulfite sequencing technology specifically designed for minute amount of DNA input, AEG team, for the first time, obtained single-base resolution DNA methylomes of early stages of primate embryos;  Collaborating with Copenhagen University, studying the effects of early feeding or gut microbiota on DNA methylation in the small intestine and functional genes of intestinal immune–metabolic pathways by multi-omics methodologies in piglets. For the last three years, AEG publish their research work in a series of international journals including Cell Research, Genome Biology, DNA Research etc.

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