Jianbin Yan

                Professor in Agricultural Synthetic Biology Center at AGIS

                PI of the Transcriptome and Metabolome Innovation Team of Agricultural Biology

                Director of Agricultural Synthetic Biology Center

                Director of Key Laboratory of Synthetic Biology at MARA

                2018-Now    Agricultural Genomics Institute at Shenzhen  Professor    

                2013-2018    Tsinghua University  Assistant & Associate Professor    

                2010-2013    Tsinghua University&MIT Postdoctoral Fellow

                2006-2010    Tsinghua University  Ph.D        

                2003-2006    Nanjing University   Master          

                1998-2002    Northwest University   Bachelor

Research Interest

Plant secondary metabolites have a variety of biological activities, being widely used in multiple fields including medicine, agriculture, food, and ecology. The metabolites can not only serve as phytohormones to regulate plant growth and development, but also serve as the largest library of active compounds on earth, providing a source of drugs for human disease treatment. Yan lab comprehensively uses technologies such as genomics, metabolomics, biochemical and molecular biology, and synthetic biology to analyze the synthesis pathway of important plant metabolites such as paclitaxel, investigate the signaling pathway and metabolic regulation mechanism of the plant hormone jasmonate, reprogram the metabolic network of plant cells, and develop efficient plant synthetic biology chassis. Prof. Jianbin Yan has published 50 papers in Science, Nature, Nature Plants, Mol Plant, Plant Cell and other journals, and obtained 17 invention patents. Many of the papers were specially evaluated, selected into Faculty Opinions or ESI highly cited papers.

Offered Courses

Synthetic biology, Core courses for cutting-edge interdisciplinary doctoral teaching

Metabolomics, Excellent Teacher Team Course of Chinese Academy of Agricultural Sciences

    Selected Publication

1. 1. Jiang B, Gao L, Wang H, Sun Y, Zhang X, Ke H, Liu S, Ma Peng, Liao Q, Wang Y, Wang H, Liu Y, Du R, Rogge T, Li W, Shang Y,  Houk K, Xiong X, Xie D, Huang S, Lei X*, Yan J* (2024) Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III. Science DOI: 10.1126/science.adj3484

2. 2. Bi G, Zhao S, Yao J, Wang H, Zhao M, Sun Y, Hou X, Haas F, Varshiney D, Prigge M, Rensing S, Jiao Y, Ma Y, Yan J*, Dai J* (2024) Near telomere-to-telomere genome of the model plant Physcomitrium patens. Nature Plants DOI: 10.1038/s41477-023-01614-7 (Featured paper)

3. 3. Yi R, Du R, Wang J, Yan J, Chu J, Yan J*, Shan X*, and Xie D* (2023) Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis. Cell Discovery 1(9): 39.

4. 4. Fang Y#*, Qin X#, Liao Q#, Du R#, Luo X, Zhou Q, Li Z, Chen  H, Jin J, Yuan Y, Sun  P, Zhang  R, Zhang J, Wang L, Cheng S, Yang X, Yan Y, Zhang X, Zhang Z, Bai S, Peer Y, Lucas W, Huang S, Yan J* (2022) The genome of homosporous maidenhair fern sheds light on the euphyllophyte evolution and defences. Nature Plants 8: 1024-1037. (Cover story)

5. 5. Hu S, Yu K, Yan J*, Shan X*, Xie D* (2022) Jasmonate perception: ligand-receptor interaction, regulation and evolution. Molecular Plant 16: 23-42.

6. 6. Du R#, Li C#*, Lin W, Lin C, Yan J* (2022) Domesticating a bacterial consortium for efficient lignocellulosic biomass conversion. Renewable Energy 189: 359-368.

7. 7. Li C#*, Xiao Y#, Sang Z, Yang Z, Xu T, Yang X, Yan J*, Lin C* (2022)  Inhibition kinetics of bio-based succinic acid production by the yeast Yarrowia lipolytica. Chemical Engineering Journal 442: 136273.

8. 8. Xiong X#, Gou J#, Liao Q#, Li Y#, Zhou Q, Bi G, Li C, Du R, Wang X, Sun T, Guo L, Liang H, Lu P, Wu Y, Zhang Z, Ro D, Shang Y, Huang S*, Yan J* (2021) The Taxus genome provides insights into paclitaxel biosynthesis. Nature Plants 7: 1026-1036. (Cover story)

9. 9. Du R#, Li C#, Pan P, Lin K, Yan J* (2021) Characterization and evaluation of a natural derived bacterial consortium for efficient lignocellulosic biomass valorization. Bioresource Technology 329: 124909.

10. 10. Li C#, Ong K, Cui Z, Sang Z, Li X, Patria R, Qi Q, Patrick F, Yan J*, Lin C* (2021) Promising advancement in fermentative succinic acid production by yeast hosts. Journal of Hazardous Materials 401: 123414.

11. 11. Li S#, Li Y#, Chen L#, Zhang C, Wang F, Li H, Wang M, Wang Y, Nan F*, Xie D*, Yan J* (2021) Strigolactone mimic 2-nitrodebranone is highly active in Arabidopsis growth and development. The Plant Journal 107: 67-76.

12. 12. Hu S#, Yang H#, Gao H, Yan J*, Xie D* (2021) Control of seed size by Jasmonate, Scinece China-Life Science 64: 1215-1226.

13. 13. Yang X#, Yan J#, Zhang Z#, Lin T, Xin T, Wang B, Wang S, Zhao J, Zhang Z, Lucas W, Li G, Huang S* (2020) Regulation of plant architecture by a novel histone acetyltransferase targeting gene bodies. Nature Plants 6: 809-822.

14. 14. Liao Q#, Du R#, Gou J, Guo L, Shen H, Liu H, Nguyen J, Ray M, Yin T, Huang S, Yan J* (2020) The genomic architecture of the sex-determining region and sex-related metabolic variation in Ginkgo biloba. The Plant Journal 104: 1399-1409.

15. 15. Yi R#, Yan J*, Xie D* (2020) Light promotes jasmonate biosynthese to regulate photomorphogenesis in Arabidopsis. Science China-Life Science 7: 943-952. (Cover story)

16. 16. Yan J#, Yao R#, Chen L, Li S, Gu M, Nan F, Xie D* (2018) Dynamic perception of jasmonates by the F-box protein COI1. Molecular Plant 11: 1237-1247.

17. 17. Yan J#*, Li S#, Gu M#, Yao R, Li Y, Chen J, Yang M, Tong J, Xiao L, Nan F*,  Xie D*(2016) Endogenous bioactive jasmonate is composed of a set of (+)-7-iso-JA-amino acid conjugates. Plant Physiology, 172(4): 2154-2164.

18. 18. Yao R#, Ming Z#, Yan L#, Li S#, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z*, Lou Z*, Xie D* (2016) DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 536(7617): 469-473.

19. 19. Li S#, Chen L#, Li Y, Yao R, Wang F, Yang M, Gu M, Nan F*, Xie D*, Yan J* (2016) Effect of GR24 stereoisomers on plant development in Arabidopsis. Molecular Plant, 9(10): 1432-1435.

20. 20. Yan J#, Li H#, Li S, Yao R, Deng H, Xie Q, Xie D* (2013) The Arabidopsis F-Box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. Plant Cell, 25(2): 486-498. (Selected into Faculty Opinions)

21. 21. Yan J#, Zhang C#, Gu M, Bai Z, Zhang W, Qi T, Cheng Z, Peng W, Luo H, Nan F*, Wang Z*, Xie D* (2009) The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor. Plant Cell, 21(8): 2220-2236. (Selected into Faculty Opinions)

Contact information

E-mail:  jianbinlab@caas.cn