Introduction

　　Guoqiang Yi, Principle Investigator, Doctoral Advisor[z2] . He has received the Overseas High-level Talents in Shenzhen in 2019. Guoqiang obtained his Bachelor and Ph.D. from China Agricultural University in 2010 and 2015, where he studied animal genetics and breeding. In 2015, he joined the Department of Molecular biology at Radboud University, to start his postdoc training. His group focuses on mining genetic loci and epigenetic regulatory elements behind important phenotypes in livestock. In the past five years, he has published more than 20 papers in Cell Reports, Blood Cancer Journal, Epigenetics & Chromatin, BMC Genomics and other journals.

　　Working Experience

　　2019.5-Present            Agricultural Genomics Institute at Shenzhen-CAAS         Research Professor            

　　2015.9-2019.3             Radboud University Nijmegen                                          Postdoctoral Fellow 

　　Education Experience

　　2010.9-2015.6              China Agricultural University                     Ph.D.                                 

　　2006.9-2010.6              China Agricultural University                     Bachelor   

　　Research Interests

　　The major focus of our group is to decipher the molecular mechanisms behind complex traits and disease in pig by integrating multi-omics approaches, which could lay a foundation for breed improvement both in theory and technique. 1) Detect potential genetic loci and regulatory elements under pork production and disease, and reveal the relationships between genetic variations and complex traits; 2) Elucidate the evolutionary history of genetic and phenotypic diversity in pig domestication by population genetics approaches; 3) Study the molecular mechanisms of developmental trajectory for porcine skeletal muscle and other key organs.

　　Major Achievements

　　1) Establishing high-resolution maps of genetic variations and pan-genome in pig, to decipher the evolutionary history of pig genetic and phenotypic diversity;

　　2) Assembling the reference genome of Debao pony, and revealing the dwarfish mechanisms by population genetics analysis;

　　3) Elucidating potential pathogenesis and targets of mycoplasmal pneumonia of swine using scRNA-seq and ChIP-seq;

　　4) Genome-wide identification of genetic loci associated with pork production and reproduction traits.

　　Selected Publication

　　1. Yi G, Wierenga ATJ, Petraglia F, Narang P, Janssen-Megens EM, Mandoli A, Merkel A,Berentsen K, Kim B, Matarese F, Singh AA, Habibi E, Prange KHM, Mulder AB, Jansen JH,Clarke L, Heath S van der Reijden BA, Flicek P, Yaspo ML, Gut , Bock C, Schuringa JJ, AltucciL, Vellenga E, Stunnenberg HG, Martens JHA. Chromatin-Based Classification of GeneticallyHeterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes. Cell Reports, 2019. 

　　2. Yi G, Mandoli A, Jussen L, Tijchon E, van Bergen MGJM, Cordonnier G, Hansen M, Kim B,Nguyen LN, Jansen PWTC, Vermeulen M, van der Reijden B, van den Akker E, Bond J, MartensJHA. CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a geneprogram that includes GATA2 and KLF1. Blood Cancer Journal, 2019.

　　3. Qu J#, Yi G#, Zhou H. p63 cooperates with CTCF to modulate chromatin architecture in skin keratinocytes. Epigenetics & Chromatin, 2019.

　　4. Yi G, Shen M, Yuan J, Sun C, Duan Z, Qu L, Dou T, Ma M, Lu J, Guo J, Chen S, Qu L, Wang  K, Yang N. Genome-wide association study dissects genetic architecture underlying longitudinalegg weights in chickens. BMC Genomics, 2015.

　　5. Yi G, Qu L, Liu J, Yan Y, Xu G, Yang N. Genome-wide patterns of copy number variation in thediversified chicken genomes using next-generation sequencing. BMC Genomics, 2014.

　　6. Yi G, Yuan J, Bi H, Yan W, Yang N, Qu L. In-Depth Duodenal Transcriptome Survey in Chickens with Divergent Feed Efficiency Using RNA-Seq. PLoS One, 2015.

　　7. Yi G, Qu L, Chen S, Xu G, Yang N. Genome-wide copy number profiling using high-density  SNP array in chickens. Animal Genetics, 2015.

　　8. Yi G, Liu W, Li J, Zheng J, Qu L, Xu G, Yang N.Genetic analysis for dynamic changes of egg weight in 2 chicken lines. Poultry Science, 2014.