Introduction

　　Gao Fei, Principle Investigator, Doctoral Advisor, deputy director of the Key Laboratory of Agricultural Genetic Data Analysis, Ministry of Agriculture, Young talent of the Chinese Academy of Agricultural Sciences, Leading talent of Shen Zhen city, member of professional committee of Epigenetics, Genetics society of China and member of Aseptic Animal Society, Chinese Association for Laboratory Animal Sciences.

　　Research focus on the role of epigenetics in normal development as well as complex diseases, especially on how environmental factors, i.e. nutrition and microbiota, may affect host epigenetics. He has published 45 peer-reviewed papers at international journals for instance Genome Biology, Cell Research etc., including 29 papers as the first or corresponding author.

　　Working Experience

　　2015.04–Present        Agricultural Genomics Institute at Shenzhen-CAAS       Principle Investigator                                                 

　　2014.10-2015.03       University of Copenhagen                                                Postdoctoral Fellow 

　　2011.02-2014.08        BGI                                                                                   Leader of Epigenetics Group 

　　2010.12-2011.12        University of Jilin                                                             Lecturer

　　Education Experience

　　2008.01-2010.12        Aarhus University                                                                        Ph.D                       

　　2004.09-2007.07        Beijing Genomics Institute, Chinese Academy of Science          Master                         

　　1999.09-2004.07        Quartermaster University of PLA                                                 Bachelor 

　　Research Field

　　Our team mainly focused on: 1) developing new methodologies of animal epigenomics; 2) epigenetic effects of nutrition and microflora and 3) epigenetic regulation of animal development and disease processes.

　　Achievements

　　Using a novel whole-genome bisulfite sequencing technology specifically designed for minute amount of DNA input, AEG team, for the first time, obtained single-base resolution DNA methylomes of early stages of primate embryos; Collaborating with Copenhagen University and Sichuan Agricultural University, studying the effects of early feeding or gut microbiota on DNA methylation in the small intestine and functional genes of intestinal immune–metabolic pathways by multi-omics methodologies in piglets. Furthermore, discovering gut microbiota changes links with rapid body-mass gain under antibiotic feeding condition. For the last three years, we publish their research work in a series of international journals including Cell Research, Genome Biology, DNA Research, Journal of Nutritional Biochemistry etc.

　　Selected Publications：

　　1. Lianqiang Che, Qi Hu, Ru Wang, Du Zhang, Cong Liu, Yihe Zhang, Guizhong Xin, Zhengfeng Fang, Yan Lin, Shengyu Xu, Bin Feng, Daiwen Chen, De Wu, Fei Gao. Inter-correlated gut microbiota and SCFAs changes upon antibiotics exposure links with rapid body-mass gain in weaned piglet model. Journal of Nutritional Biochemistry 74 (2019) 108246

　　2. Du Zhang, Qi Hu, Yue Hu, Yihe Zhang, Yu Zhang, Peng Cui, Yunyun Zhou, Xuefeng Liu, Jun Jiang, Linsen Yang, Huiliang Yu, Hui Yao, Yucheng Zhao, Xinxing Liu, Yili Liang, Kai Zou, Jiemeng Tao, Diqiang Li, Xueduan Liu, Yuguang Zhang, Fei Gao, Epigenetic and transcriptional signatures of ex situ conserved golden snubnosed monkeys (Rhinopithecus roxellana). Biological Conservation 237 (2019) 175–184

　　3. Y. Chen, Y. Zhang, J. Wang, N. Chen, W. Fang, J. Zhong, Y. Liu, R. Qin, X. Yu, Z. Sun* and F. Gao*, A 17 gene panel for non-small-cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial–mesenchymal transition. Molecular Oncology. 2019 Apr 9; 10.1002/1878-0261.12491

　　4. X. Pan, D. Gong, F. Gao* & P. T. Sangild*, Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs. Epigenomics. 2018 Apr 1;10(4):395-408

　　5. P. Karlskov-Mortensen, H. F. Proschowsky, F. Gao and M. Fredholm, Identification of the mutation causing progressive retinal atrophy in Old Danish Pointing Dog. Animal Genetics, 10.1111/age.12659

　　6. J. Sun, X. Pan, L. I. Christiansen, X. Yuan, K. Skovgaard, D. E. W. Chatterton, S. S. Kaalund, F. Gao, P. T. Sangild and S. Pankratova, Necrotizing enterocolitis is associated with acute brain responses in preterm pigs. Journal of Neuroinflammations 10.1186/s12974-018-1201-x

　　7. Pan X, Gong D, Nguyen DN, Zhang X, Hu Q, Lu H, Fredholm M, Sangild PT, Gao F. Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs. DNA Research 2018, 0(0), 1–10.

　　8. Hu Y, Hu L, Gong D, Lu H, Xuan Y, Wang R, Wu, Chen D, Zhang K, Gao F*, Che L*. Genome-wide DNA methylation analysis in jejunum of Sus scrofa with intrauterine growth restriction. Mol Genet Genomics 2018.

　　9. F. Gao, Y. Niu, Y. Eve Sun, H. Lu, Y. Chen, S. Li, Y. Kang, Y. Luo, C. Si, J. Yu, C. Li, N. Sun, W. Si, H. Wang, W. Ji, T. Tan, De novo DNA methylation during monkey pre-implantation embryogenesis, Cell Research (2017) :1-14.