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Gengjie Jia Lab

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Gengjie Jia
Researcher
Ph.D., Singapore-MIT Alliance (National University of Singapore), 2013
Keywords: Biomedical Informatics; Individual Nutrition; Electronic Healthy Records; Natural Language Processing; Biomolecular Network Modeling; Subtypes of Disease
Email: jiagengjie@caas.cn
Research Interest
Many complex diseases, such as asthma, have long been recognized as heterogeneous, complex syndromes, both clinically and pathogenetically. In past studies, we observed that, across subgroups, asthma-associated clinical features varied dramatically, and medication uses were very different. Based on the identification of disease subgroups, we hope to design an individualized diet program to assist in the prevention and treatment of diseases. So we went through algorithm development for analyzing multi-dimensional big health data focus on discerning subtypes of complex diseases (using comorbidity pattern recognition and multi-omics data analysis), parsing their underlying genetic bases, and illuminating the tripartite relationship among human digestive systems, microbiota therein, and food nutrition. This work will provide theoretical support for both the diagnosis and treatment of complex chronic diseases and the development of the individual nutritional design.
Selected Publications
1.	G. Jia, Y. Li, H. Zhang, I. Chattopadhyay, A. B. Jensen, D. R. Blair, L. Davis, P. N. Robinson, T. Dahlén, S. Brunak, M. Benson, G. Edgren, N. J. Cox, X. Gao, A. Rzhetsky, Estimating Heritability and Genetic Correlations from Large Health Datasets in the Absence of Genetic Data, Nature Communications, 10, 5508 (2019). (corresponding authors)
2.	G. Jia, G. Stephanopoulos, R. Gunawan*, Ensemble Kinetic Modeling of Metabolic Networks from Dynamic Metabolic Profiles, Metabolites, 2 (4), 891–912 (2012).
3.	G. Jia, G. Stephanopoulos, R. Gunawan*, Incremental Parameter Estimation of Kinetic Metabolic Network Models, BMC Systems Biology, 6, 142 (2012).
4.	G. Jia, G. Stephanopoulos, R. Gunawan*, Parameter Estimation of Kinetic Models from Metabolic Profiles: Two-phase Dynamic Decoupling Method, Bioinformatics, 27 (14), 1964–1970 (2011).
5.	B. Chicoine, A. Rivelli, V. Fitzpatrick*, L. Chicoine, G. Jia, A. Rzhetsky, Prevalence of Common Disease Conditions in a Large Cohort of Individuals with Down Syndrome in the United States, Journal of Patient-Centered Research and Reviews, 8(2), 86-97 (2021).
6.	X. Zhong, Z. Yin, G. Jia, D. Zhou, Q. Wei, A. Faucon, P. Evans, E. R. Gamazon, B. Li, R. Tao, A. Rzhetsky, L. Bastarache, N. J. Cox, Electronic Health Record Phenotypes Associated with Genetically Regulated Expression of CFTR and Application to Cystic Fibrosis, Genetics in Medicine, 22, 1191–1200 (2020).
7.	C. Zhang, H. Tu, G. Jia, T. Mukhtar, V. Taylor, A. Rzhetsky, S. Tay*, Ultra-multiplexed Analysis of Single-cell Dynamics Reveals Logic Rules in Differentiation, Science Advances, 5 (2019).
8.	G. Jia, R. Gunawan*, Construction of Kinetic Model Library of Metabolic Networks, IFAC Proceedings, 45 (15), 952-957 (2012).
9.	G. Jia, G. Stephanopoulos*, Incremental Parameter Estimation and Ensemble Kinetic Modeling of Metabolic Networks, Proceedings of AIChE Annual Meeting (2012).
10.	G. Jia, G. Stephanopoulos, R. Gunawan*, Construction of Kinetic Model Library of Metabolic Networks from Dynamic Profiles, 8th International Workshop on Computational Systems Biology (2011).

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