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The Agricultural Genome Institute at Shenzhen (AGIS) was launched jointly with the Shenzhen government in 2014, under the auspices of the Chinese Academy of Agricultural Sciences, with support from the Ministry of Agriculture and Rural Affairs and the Shenzhen Government. AGIS is dedicated to understanding and harnessing the genomes that are critical to global agricultural production, by integrating biology and big data science. In this regard, AGIS is currently employing six major researches and development platforms, namely Bioinformatics and Omics Technologies, Synthetic Biology in Agriculture and Food, Plant Genomics and Crop Breeding, Animal Genomics and Livestock Breeding, Environmental and Ecological Genomics, and Big Data in Food and Nutrition. The long-term mission of AGIS is to make disruptive innovation to promote the sustainable development of global agriculture, to serve the personalized food supply system, and to improve human health and the social status of farmers.