Overview

We focus on synthetic breeding, plant secondary metabolite research and artificial chromosomes development. We are performing gene network data mining and metabolic pathways analysis. We are promoting genome-wide design breeding and omics-driven plant artificial design to build a modern agricultural breeding research platform.

Research Direction

The Synthesis Biology Center is built on the basis of the big biology data and the big scientific team to solve the cutting-edge problems in agricultural synthetic biology. We focus on synthetic breeding, plant secondary metabolite research and artificial chromosomes development. We are performing gene network data mining and metabolic pathways analysis. We are promoting genome-wide design breeding and omics-driven plant artificial design to build a modern agricultural breeding research platform. We have been approved as "Key Laboratory of Synthetic Biology of the Ministry of Agriculture and Rural Development", "Shenzhen Key Laboratory of Agricultural Synthetic Biology", "Shenzhen Hybrid Potato Engineering Research Center".

1. Based on omics data, through research on the pathways and regulatory networks of crop agronomic trait genes, combined with the optimal design of molecular interaction network modules. Using whole-genome design, aiming at excellent agronomic traits and metabolite content, we will establish a precise directional breeding platform to accelerate the cultivation of new varieties with high yield and high quality.

2. By establishing a functional multi-omics plant secondary metabolite analysis and design system, we mining important agronomic traits, functional small molecule related pathways and regulatory networks. Combined with whole genome editing and artificial chromosome synthesis technology, we will establish a plant chassis biology-based anabolic construction system for the development and industrialization of plant resources of specific social and economic importance.

3. We will establish a technological platform for the design and modification, chromosome editing, synthesis and assembly of ultra-long eukaryotic chromosomes, and synthesize artificial chromosomes that can be stably existed in model plants or crop plants, such as small standing bowl moss or potatoes. Through the development of artificial chromosome transplantation and activation technology, we will construct plants with artificial chromosomes carrying multiple resistance genes and different natural product metabolic pathways, and provide the basis for the realization of relevant industrial applications based on plant artificial chromosomes.