Our research focuses on designing algorithms to solve key problems in genomics such as genome assembly, haplotype phasing and variant calling. We integrate cutting-edge genomics technologies such as Pacbio HiFi, Oxford Nanopore, Hi-C, BioNano and 10x Genomics with computational methods such as combinatorial optimization algorithms, graph theory, statistics and machine learning to develop novel, accurate and efficient algorithms to solve computational problems like polyploid genome assembly, haplotype reconstruction, telomere to telomere assembly and metagenome assembly. And we apply computational methods developed to important scientific discovery.