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闫建斌课题组

闫建斌课题组


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姓名:

闫建斌    

职称:

研究员,博导,首批国家“神农青年英才”

合成生物学中心主任,农业农村部合成生物学重点实验室主任

电子邮件:

jianbinlab@caas.cn


 简介:


闫建斌,研究员,博导,首批国家“神农青年英才”合成生物学中心主任,农业农村部合成生物学重点实验室主任


工作经历

2018–至今          中国农业科学院深圳农业基因组研究所 研究员

2013-2018       清华大学                                          助理研究员&副研究员  

2010-2013             清华大学&美国麻省理工学院           博士后


教育经历

2006-2010             清华大学 博士  

2003-2006             南京大学 硕士        

1998-2002             西北大学 本科


 研究领域:


植物提供着人类赖以生存的食物、药物、能源和环境。植物在长期进化过程中产生了大量结构复杂多样的代谢产物,可作为植物激素等重要内源分子调控植物生长发育及环境响应,同时作为地球上最大的活性化合物库,提供人类治疗疾病的药物来源。闫建斌课题组长期从事植物代谢与合成生物学研究工作,研究紫杉醇等重要植物代谢物的生物合成途径,研究植物激素茉莉素的信号途径与代谢调控机制,重编程植物细胞代谢网络,发展植物合成生物学与生物制造底盘。揭示了红豆杉成为“植物大熊猫”的遗传基础,鉴定了紫杉醇生物途径的基因簇和关键合成酶,建立了紫杉醇异源生物合成路线;揭示了激素类天然产物茉莉素代谢调控分子机制,阐明了茉莉素生物合成途径的演化规律等。在Science、Nature Plants、Molecular Plant、Plant Cell等学术期刊发表论文50篇,获得国家发明专利等20余项。多篇论文获专评、入选Faculty Opinions或ESI高被引论文。


 开设课程:


《合成生物学》,前沿交叉学科博士教学核心课程

《代谢组学》,中国农科院优秀教师团队课程


 代表论著:


代表论文:

1. Jiang B, Gao L, Wang H, Sun Y, Zhang X, Ke H, Liu S, Ma Peng, Liao Q, Wang Y, Wang H, Liu Y, Du R, Rogge T, Li W, Shang Y, Houk K, Xiong X, Xie D, Huang S, Lei X*, Yan J* (2024) Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III. Science DOI: 10.1126/science.adj3484  (1TopIF56.9)

2. Bi G, Zhao S, Yao J, Wang H, Zhao M, Sun Y, Hou X, Haas F, Varshiney D, Prigge M, Rensing S, Jiao Y, Ma Y, Yan J*, Dai J* (2024) Near telomere-to-telomere genome of the model plant Physcomitrium patens. Nature Plants DOI: 10.1038/s41477-023-01614-7 (1TopIF18)

3. Yi R, Du R, Wang J, Yan J, Chu J, Yan J*, Shan X*, and Xie D* (2023) Dioxygenase JID1 mediates the modification of OPDA to regulate jasmonate homeostasis. Cell Discovery 1(9): 39. (1TopIF33.5)

4. Fang Y#*, Qin X#, Liao Q#, Du R#, Luo X, Zhou Q, Li Z, Chen  H, Jin J, Yuan Y, SunP, Zhang  R, Zhang J, Wang L, Cheng S, Yang X, Yan Y, Zhang X, Zhang Z, Bai S, Peer Y, Lucas W, Huang S, Yan J* (2022) The genome of homosporous maidenhair fern sheds light on the euphyllophyte evolution and defences. Nature Plants 8: 1024-1037.1TopIF18封面论文)

5. Hu S, Yu K, Yan J*, Shan X*, Xie D* (2022) Jasmonate perception: ligand-receptor interaction, regulation and evolution. Molecular Plant 16: 23-42. 1TopIF27.5

6. Du R#, Li C#*, Lin W, Lin C, Yan J* (2022) Domesticating a bacterial consortium for efficient lignocellulosic biomass conversion. Renewable Energy 189: 359-368.1TopIF8.7

7. Li C#*, Xiao Y#, Sang Z, Yang Z, Xu T, Yang X, Yan J*, Lin C* (2022) Inhibition kinetics of bio-based succinic acid production by the yeast Yarrowia lipolytica. Chemical Engineering Journal 442: 136273.1TopIF15.1

8. Xiong X#, Gou J#, Liao Q#, Li Y#, Zhou Q, Bi G, Li C, Du R, Wang X, Sun T, Guo L, Liang H, Lu P, Wu Y, Zhang Z, Ro D, Shang Y, Huang S*, Yan J* (2021) The Taxus genome provides insights into paclitaxel biosynthesis. Nature Plants 7: 1026-1036.1TopIF18,封面论文)

9. Du R#, Li C#, Pan P, Lin K, Yan J* (2021) Characterization and evaluation of a natural derived bacterial consortium for efficient lignocellulosic biomass valorization. Bioresource Technology 329: 124909.1TopIF11.4

10. Li C#, Ong K, Cui Z, Sang Z, Li X, Patria R, Qi Q, Patrick F, Yan J*, Lin C* (2021) Promising advancement in fermentative succinic acid production by yeast hosts. Journal of Hazardous Materials 401: 123414. 1TopIF13.6

11. Li S#, Li Y#, Chen L#, Zhang C, Wang F, Li H, Wang M, Wang Y, Nan F*, Xie D*, Yan J* (2021) Strigolactone mimic 2-nitrodebranone is highly active in Arabidopsis growth and development. The Plant Journal 107: 67-76.1TopIF7.2

12. Hu S#, Yang H#, Gao H, Yan J*, Xie D* (2021) Control of seed size by Jasmonate, Scinece China-Life Science 64: 1215-1226.1TopIF9.1

13. Yang X#, Yan J#, Zhang Z#, Lin T, Xin T, Wang B, Wang S, Zhao J, Zhang Z, Lucas W, Li G, Huang S* (2020) Regulation of plant architecture by a novel histone acetyltransferase targeting gene bodies. Nature Plants 6: 809-822.1TopIF18

14. Liao Q#, Du R#, Gou J, Guo L, Shen H, Liu H, Nguyen J, Ray M, Yin T, Huang S, Yan J* (2020) The genomic architecture of the sex-determining region and sex-related metabolic variation in Ginkgo biloba. The Plant Journal 104: 1399-1409.1TopIF7.2

15. Yi R#, Yan J*, Xie D* (2020) Light promotes jasmonate biosynthese to regulate photomorphogenesis in Arabidopsis. Science China-Life Science 7: 943-952.1TopIF9.1,封面论文)

16. Yan J#, Yao R#, Chen L, Li S, Gu M, Nan F, Xie D* (2018) Dynamic perception of jasmonates by the F-box protein COI1. Molecular Plant 11: 1237-1247.1TopIF27.5, 入选《2018年中国植物科学若干领域重要研究进展》

17. Yan J#*, Li S#, Gu M#, Yao R, Li Y, Chen J, Yang M, Tong J, Xiao L, Nan F*, Xie D*(2016) Endogenous bioactive jasmonate is composed of a set of (+)-7-iso-JA-amino acid conjugates. Plant Physiology, 172(4): 2154-2164.1TopIF7.4, 入选《2016年中国植物科学若干领域重要研究进展》

18. Yao R#, Ming Z#, Yan L#, Li S#, Wang F, Ma S, Yu C, Yang M, Chen L, Chen L, Li Y, Yan C, Miao D, Sun Z, Yan J, Sun Y, Wang L, Chu J, Fan S, He W, Deng H, Nan F, Li J, Rao Z*, Lou Z*, Xie D* (2016) DWARF14 is a non-canonical hormone receptor for strigolactone. Nature, 536(7617): 469-473.1TopIF64.8

19. Li S#, Chen L#, Li Y, Yao R, Wang F, Yang M, Gu M, Nan F*, Xie D*, Yan J* (2016) Effect of GR24 stereoisomers on plant development in Arabidopsis. Molecular Plant, 9(10): 1432-1435.1TopIF27.5

20. Yan J#, Li H#, Li S, Yao R, Deng H, Xie Q, Xie D* (2013) The Arabidopsis F-Box protein CORONATINE INSENSITIVE1 is stabilized by SCFCOI1 and degraded via the 26S proteasome pathway. Plant Cell, 25(2): 486-498.1TopIF11.6, 入选Faculty Opinions

21. Yan J#, Zhang C#, Gu M, Bai Z, Zhang W, Qi T, Cheng Z, Peng W, Luo H, Nan F*, Wang Z*, Xie D* (2009) The Arabidopsis CORONATINE INSENSITIVE1 protein is a jasmonate receptor. Plant Cell, 21(8): 2220-2236.1TopIF11.6, 入选Faculty Opinions



闫建斌课题组更新于2024年2月5日


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