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贾耿介课题组

贾耿介课题组

Gengjie (Jay) Jia Lab

jiagengjie@caas.cn

  

  课题组长

  贾耿介,研究员、博士生导师,入选中国农科院青年英才、深圳海外高层次人才、国际计算生物学协会。2008年于中国科学技术大学本科毕业,2013年在新加坡国立大学和麻省理工学院联合培养项目取得博士学位。研究专长包括生物信息学、健康表型大数据(如电子病历和体检报告)挖掘、精准营养、自然语言处理、生物分子网络建模、以及多组学数据分析。以第一或通讯(含共同)作者在Nature Computational Science, Nature Communications、Metabolites、Bioinformatics 等发表学术论文

  

研究方向

通过开发分析多维度健康大数据和营养/膳食大数据的算法

1. 发掘复杂疾病亚型(通过共病模式的系统识别和多组学分析),解析其遗传学基础,进一步设计亚型特异的精准营养干预措施;

2. 描述疾病并发的模式规律,建立并发症风险预测模型,寻找最优膳食和(或)药物组合;

3. 阐释人体消化等系统、其间微生物群落、和食品营养三方的相互作用关系。


  工作经历

  2021/1至今                  中国农业科学院深圳农业基因组研究所, 研究员

  2016/6 – 2020/12       芝加哥大学, 博士后

  2013/1 – 2016/5         CGG公司数据处理分部, 地球物理学家

  

  教育经历

  2008/7 – 2013/1       新加坡-麻省理工学院联盟化学与制药工程博士

  2011/4 – 2011/10     瑞士苏黎世联邦理工学院,访问学习;

  2004/9 – 2008/6       中国科学技术大学,生物学学士。

 

       代表论文

(#co-first, *co-corresponding)

1.G. Jia#*, Y. Li#, …, X. Gao*, A. Rzhetsky*.  The high-dimensional space of human diseases built from diagnosis records and mapped to genetic loci. Nature Computational Science (2023).

 2 .G. Jia, Zhong, X., Im, H.K. et al. Discerning asthma endotypes through comorbidity mapping. Nature Communications 13, 6712 (2022).

      3.G. Jia, Y. Li, H. Zhang, I. Chattopadhyay, A. B. Jensen, D. R. Blair, L. Davis, P. N. Robinson, T. Dahlén, S. Brunak, M. Benson, G. Edgren, N. J. Cox, X. Gao, A. Rzhetsky*, Estimating Heritability and Genetic Correlations from Large Health Datasets in the Absence of Genetic Data, Nature Communications, 10, 5508 (2019).   (*corresponding authors)

      4.G. Jia, G. Stephanopoulos, R. Gunawan*, Ensemble Kinetic Modeling of Metabolic Networks from Dynamic Metabolic Profiles, Metabolites, 2 (4), 891–912 (2012).

      5.G. Jia, G. Stephanopoulos, R. Gunawan*, Incremental Parameter Estimation of Kinetic Metabolic Network Models, BMC Systems Biology, 6, 142 (2012).

      6.G. Jia, G. Stephanopoulos, R. Gunawan*, Parameter Estimation of Kinetic Models from Metabolic Profiles: Two-phase Dynamic Decoupling Method, Bioinformatics, 27 (14), 1964–1970 (2011).

      7.B. Chicoine, A. Rivelli, V. Fitzpatrick*, L. Chicoine, G. Jia, A. Rzhetsky, Prevalence of Common Disease Conditions in a Large Cohort of Individuals with Down Syndrome in the United States, Journal of Patient-Centered Research and Reviews, 8(2), 86-97 (2021).

      8.X. Zhong*, Z. Yin, G. Jia, D. Zhou, Q. Wei, A. Faucon, P. Evans, E. R. Gamazon, B. Li, R. Tao, A. Rzhetsky, L. Bastarache, N. J. Cox*, Electronic Health Record Phenotypes Associated with Genetically Regulated Expression of CFTR and Application to Cystic Fibrosis, Genetics in Medicine, 22, 1191–1200 (2020).

      9.C. Zhang, H. Tu, G. Jia, T. Mukhtar, V. Taylor, A. Rzhetsky, S. Tay*, Ultra-multiplexed Analysis of Single-cell Dynamics Reveals Logic Rules in Differentiation, Science Advances, 5 (2019).

      10.G. Jia, R. Gunawan*, Construction of Kinetic Model Library of Metabolic Networks, IFAC Proceedings, 45 (15), 952-957 (2012).

     11.G. Jia, G. Stephanopoulos*, Incremental Parameter Estimation and Ensemble Kinetic Modeling of Metabolic Networks, Proceedings of AIChE Annual Meeting (2012).

     12.G. Jia, G. Stephanopoulos, R. Gunawan*, Construction of Kinetic Model Library of Metabolic Networks from Dynamic Profiles, 8th International Workshop on Computational Systems Biology (2011).


贾耿介课题组更新于2023年9月

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