高飞

高飞                               

研究员、博士生导师

动物基因组中心 首席科学家

flys828@qq.com

 

个人简介：

高飞 ，研究员，博士生导师。基因组所-动物基因组中心- 农业表观基因组学创新团队首席科学家，2010获得丹麦奥胡斯大学博士学位。2013年获得BMC杂志颁发的面向全球评选的Open Date 奖项，同年被评选为中国遗传学会表观遗传专业委员会和青年委员会委员。2014年获得吉林省科技进步一等奖。研究方向为动物发育、健康及与环境互作中的表观遗传学调控机制。

 

工作经历：

2011年2月-2014年8月，团队负责人，深圳华大基因研究院

2014年10月-2015年3月，博士后，哥本哈根大学营养与健康学院

2015年4月-至今，团队首席，中国农业科学院深圳农业基因组研究所

 

学习经历：

1999年9月-2004年7月，兽医学学士，军需大学兽医学

2004年9月-2007年7月，理学硕士，中国科学院北京基因组研究所遗传学

2008年1月-2010年12月，理学博士，奥胡斯大学遗传学

 

所获荣誉：

2013年获得Open Data奖项

2013年获得深圳市海外高层次人才称号

2014年获得吉林省科学技术一等奖

2017年入选中国农业科学院青年英才A类计划

2017年担任农业部基因数据分析重点实验室副主任

 

学术论文：

第一作者论文

1.Zhu Y, Lu H, Zhang D, Li M, Sun X, Wan L, et al. Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer. Clin Epigenetics. 2018;10:30.

2.Pan X#, Gong D#, Gao F*, et al. Diet-dependent changes in the intestinal DNA methylome after introduction of enteral feeding in preterm pigs. Epigenomics, 2018.

3.Hu, Y#., Hu, L#., Gong, D., Lu, H., Xuan, Y., Wang, R., Wu, Chen, D., Zhang, K*., Gao, F*., et al. Genome-wide DNA methylation analysis in jejunum of Sus scrofa, with intrauterine growth restriction. Molecular Genetics & Genomics Mgg, 2018:1-12.

4.Pan X#, Gong D#, Nguyen DN, Zhang X, Hu Q, Lu H, Fredholm M, Sangild PT*, Gao F*.Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs. Dna Research An International Journal for Rapid Publication of Reports on Genes & Genomes, 2018.

5.Ming Li#, Fei Gao#, Yudong Xia#, Yi Tang, Wei Zhao, Congcong Jin, Huijuan Luo, Junwen Wang, Qingshu Li, Yalan Wang*: Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue. Scientific Reports 08/2016; 6., DOI:10.1038/srep31826

6.Dong-Xu He#, Feng Gu#, Fei Gao#, Jun-jun Hao#, Desheng Gong, Xiao-Ting Gu, Ai-Qin Mao, Jian Jin, Li Fu, Xin Ma*: Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer. Scientific Reports 04/2016; 6., DOI:10.1038/srep24706

7.Young-Hee Jeong#, Hanlin Lu#, Chi-Hun Park#, Meiyan Li, Huijuan Luo, Joung Joo Kim, Siyang Liu, Kyeong Hee Ko, Shujia Huang, In Sung Hwang, Mi Na Kang, Desheng Gong, Kang Bae Park, Eun Ji Choi, Jung Hyun Park, Yeon Woo Jeong, Changjong Moon, Sang-Hwan Hyun, Nam Hyung Kim, Eui-Bae Jeung, Huanming Yang, Woo Suk Hwang*, Fei Gao*: Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer. Scientific Reports 08/2016; 6., DOI:10.1038/srep3108

8.Fei Gao#, Huifang Liang#, Hanlin Lu, Junwen Wang, Meng Xia, Zhimei Yuan, Yu Yao, Tong Wang, Xiaolong Tan, Arian Laurence, Hua Xu, Jingjing Yu, Wei Xiao, Wei Chen, Ming Zhou, Xiuqing Zhang, Qian Chen*, Xiaoping Chen*: Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach.Clinical Epigenetics 08/2015; 7(1)., DOI:10.1186/s13148-015-0121-1

9.Hanlin Lu#, Zhimei Yuan#, Tao Tan#, Junwen Wang, Juyong Zhang, Hui-Juan Luo, Yudong Xia, Weizhi Ji*, Fei Gao*: Improved tagmentation-based whole-genome bisulfite sequencing for input DNA from less than 100 mammalian cells. Epigenomics 02/2015; 7(1)., DOI:10.2217/epi.14.76

10.Fei Gao#, Yudong Xia#, Junwen Wang#, Zhilong Lin, Ying Ou, Xing Liu, Weilong Liu, Boping Zhou, Huijuan Luo, Baojin Zhou, Bo Wen, Xiuqing Zhang*, Jian Huang*: Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma. Genome Biology 12/2014; 15(12)., DOI:10.1186/s13059-014-0533-9

11.Fei Gao#, Juyong Zhang#, Pingping Jiang#, Desheng Gong#, Jun-Wen Wang, Yudong Xia, Mette Viberg Østergaard, Jun Wang*, Per Torp Sangild*: Marked methylation changes in intestinal genes during the perinatal period of preterm neonates. BMC Genomics 08/2014; 15(1-1)., DOI:10.1186/1471-2164-15-716

12.Fei Gao#, Junwen Wang#, Guanyu Ji#, Siyang Liu, Yu Yao, Tong Wang, Honglong Wu, Yudong Xia, Desheng Gong, Hui Jiang, Huanming Yang*, Xiuqing Zhang*: Clustering of Cancer Cell Lines Using A Promoter-Targeted Liquid Hybridization Capture-Based Bisulfite Sequencing Approach. Technology in cancer research & treatment 03/2014;, DOI:10.7785/tcrt.2012.500416

13.Fei Gao#, Rui Wang#, Mingyuan Liu*: Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism. Frontiers in Physiology 01/2014; 4., DOI:10.3389/fphys.2013.00410

 

既非第一作者又非通讯作者论文（仅不列此项时可删除该标题，序号按实际情况编排）

1.Gregory Livshits#, Ida Malkin#, Maxim B Freidin, Yudong Xia, Fei Gao, Jun Wang, Timothy D Spector, Alex MacGregor, Jordana T Bell*, Frances MK Williams*: Genome-wide methylation analysis of a large population sample shows neurological pathways involvement in chronic widespread musculoskeletal pain (CWP). Pain 02/2017;, DOI:10.1097/j.pain.0000000000000880

2.Christopher G Bell#, Yudong Xia#, Wei Yuan#, Fei Gao, Kirsten Ward, Leonie Roos, Massimo Mangino, Pirro G Hysi, Jordana Bell, Jun Wang*, Timothy D Spector*: Novel regional age-associated DNA methylation changes within human common disease-associated loci. Genome Biology 10/2016; 17(1)., DOI:10.1186/s13059-016-1051-8

3.Gregory Livshits, Fei Gao, Ida Malkin, Maria Needhamsen, Yudong Xia, Wei Yuan, Christopher G Bell, Kirsten Ward, Yuan Liu, Jun Wang*, Jordana T Bell*, Tim D Spector*: Contribution of heritability and epigenetic factors to skeletal muscle mass variation in UK twins. The Journal of Clinical Endocrinology and Metabolism 05/2016; 101(6)., DOI:10.1210/jc.2016-1219

4.Zhiming He#, Hanlin Lu#, Huijuan Luo, Fei Gao, Tong Wang, Yu Gao, Qun Fang*, Junwen Wang*: The promoter methylomes of monochorionic twin placentas reveal intrauterine growth restriction-specific variations in the methylation patterns. Scientific Reports 02/2016; 6., DOI:10.1038/srep20181

5.Wei Yuan#, Yudong Xia#, Christopher G Bell, Idil Yet, Teresa Ferreira, Kirsten J Ward, Fei Gao, A Katrina Loomis, Craig L Hyde, Honglong Wu, Hanlin Lu, Yuan Liu, Kerrin S Small, Ana Viñuela, Andrew P Morris, María Berdasco, Manel Esteller, M Julia Brosnan, Panos Deloukas, Mark I McCarthy, Sally L John, Jordana T Bell*, Jun Wang*, Tim D Spector*: An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins. Nature Communications 12/2014; 5., DOI:10.1038/ncomms6719

6.Ming Zhao#, Siyang Liu#, Shuangyan Luo, Honglong Wu, Meini Tang, Wenjing Cheng, Qing Zhang, Peng Zhang, Xinhai Yu, Yudong Xia, Na Yi, Fei Gao, Li Wang, Susan Yung, Tak Mao Chan, Amr H Sawalha, Bruce Richardson, M Eric Gershwin, Ning Li*, Qianjin Lu*: DNA methylation and mRNA and microRNA expression of SLE CD4+ T cells correlate with disease phenotype. Journal of Autoimmunity 08/2014; 54., DOI:10.1016/j.jaut.2014.07.002

7.Matthew N Davies#, Lutz Krause#, Jordana T Bell, Fei Gao, Kirsten J Ward, Honglong Wu, Hanlin Lu, Yuan Liu, Pei-Chein Tsai, David A Collier, Therese Murphy, Emma Dempster, Jonathan Mill, Alexis Battle, Sara Mostafavi, Xiaowei Zhu, Anjali Henders, Enda Byrne, Naomi R Wray, Nicholas G Martin, Tim D Spector*, Jun Wang*: Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. Genome biology 04/2014; 15(4)., DOI:10.1186/gb-2014-15-4-r56

8.J T Bell#, A.K. Loomis#, L M Butcher, F Gao, B Zhang, C L Hyde, J Sun, H Wu, K Ward, J Harris, S Scollen, M N Davies, L C Schalkwyk, J Mill, The Muther Consortium, F M K Williams, N Li, L John*, T D Spector*: Differential methylation of the TRPA1 promoter in pain sensitivity. Nature Communications 02/2014; 5(2978)., DOI:10.1038/ncomms3978

9.Jian Li#, Kai Wang#, Fei Gao, Thomas D Jensen, Shengting T Li, Paula M DeAngelis, Steen Kølvraa, Charlotte Proby, Ola Forslund, Lars Bolund*, Ole Petter F Clausen*: Array Comparative Genomic Hybridization of Keratoacanthomas and Squamous Cell Carcinomas: Different Patterns of Genetic Aberrations Suggest Two Distinct Entities. Journal of Investigative Dermatology 04/2012; 132(8)., DOI:10.1038/jid.2012.104

10.Xue Bai#, Xiuping Wu#, Xuelin Wang#, Xiaolei Liu, Yanxia Song, Fei Gao, Yajuan Miao, Lu Yu, Bin Tang, Xinrui Wang, Blaga Radu, Isabelle Vallee, Pascal Boireau, Feng Wang, Ying Zhao*, Mingyuan Liu*: Inhibition of mammalian muscle differentiation by excretory secretory products of muscle larvae of Trichinella spiralis in vitro. Parasitology Research 12/2011; 110(6)., DOI:10.1007/s00436-011-2789-2

11.Junwen Wang#, Hui Jiang#, Guanyu Ji, Fei Gao, Mingzhi Wu, Jihua Sun, Huijuan Luo, Jinghua Wu, Renhua Wu*, Xiuqing Zhang*: High resolution profiling of human exon methylation by liquid hybridization capture-based bisulfite sequencing. BMC Genomics 12/2011; 12(1)., DOI:10.1186/1471-2164-12-597

12. Xue Bai#, Xiuping Wu#, Xuelin Wang, Zhenhong Guan, Fei Gao, Jianli Yu, Lu Yu, Bin Tang, Xiaolei Liu, Yanxia Song, Xinrui Wang, Blaga Radu, Pascal Boireau, Feng Wang*, Mingyuan Liu*: Regulation of cytokine expression in murine macrophages stimulated by excretory/secretory products from Trichinella spiralis in vitro. Molecular and Cellular Biochemistry 09/2011; 360(1-2)., DOI:10.1007/s11010-011-1046-4

13. Li-hong Yuan#, Bao-quan Fu#, Ming-yuan Liu#, Fei Gao, Ya-lan Zhang, Xiu-ping Wu, Ben-fu Lin, Lian-rui Li, Qiang Lu, Qi-jun Chen*, Pascal Boireau*: [Expression and antigenicity analysis of p46000 antigen from newborn larvae of Trichinella spiralis]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 03/2005; 23(1).