费启立

　　费启立研究员

　　中国农业科学院（深圳）农业基因组研究所

　　深圳市大鹏新区鹏飞路7号 邮编：518124

　　Email: feiqili@caas.cn

　　出生时间：1989年10月2日

　　出生地点：陕西咸阳

 

　　学习经历

　　2012.1-2016.8       特拉华大学植物与土壤科学系，获博士学位

　　2012.1-2015.12     特拉华大学生物信息学系，获硕士学位

　　2007.9-2011.7       西北农林科技大学生物工程系，获学士学位

 

　　工作经历

　　2019.9-至今          中国农业科学院（深圳）农业基因组研究所　　研究员，博士生导师

　　2016.9-2019.8       芝加哥大学化学系　　博士后

　　

　　费启立研究员长期从事植物小分子RNA领域的研究，以及表观转录组学，尤其是RNA甲基化修饰N6-methyladenosine (m6A)。他阐明了植物miRNA介导产生phasiRNA这一生物合成途径的分子机制以及生物学功能，揭示了m6A结合蛋白YTHDF2在人类细胞中通过促进m6A修饰的转录本RNA的降解从而调控细胞周期的分子机制。以第一作者在PLOS Biology, PNAS, Plant Cell，Plant Journal，Plant Biotechnology Journal，Journal of Experimental Botany等杂志发表多篇论文。并担任Trends in Plant Science、Plant Cell、Plant Physiology、Bioinformatics等期刊审稿人。

 

　　部分论文†: 通讯作者

　　1. Fei, Q.*, Zou, Z.*, Roundtree, I.A., Sun, H.L., and C. He†. (2020) YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators. PLOS Biology (accepted). (*co-first authors)

　　2. Bi, H.*, Fei, Q.*, Li, R., Liu, B., Xia, R., Char, S.N., Meyers, B.C., and B. Yang†. (2019) Disruption of miRNA sequences by TALENs and CRISPR/Cas9 induces varied lengths of miRNA production. Plant Biotechnology Journal. doi: 10.1111/pbi.13315. (*co-first authors)

　　3. Fei, Q., Yu, Y., Liu, L., Zhang, Y., Baldrich, P., Dai, Q., Chen, X., and B.C. Meyers†. (2018) Biogenesis of a 22-nt microRNA in Phaseoleae species by precursor-programmed uridylation. Proceedings of the National Academy of Sciences of the United States of America. 115(31):8037-8042.

　　4. Fei, Q.*, Yang, L.*, Liang, W., Zhang, D. †, and B.C. Meyers†. (2016) Dynamic changes of small RNAs in rice spikelet development reveal specialized reproductive phasiRNA pathways. Journal of Experimental Botany. 67(21):6037-6049. (*co-first authors)

　　5. Fei, Q., Zhang, Y., Xia, R., B.C. Meyers†. (2016) Small RNAs add zing to the Zig-Zag-Zig model of plant defenses. Molecular Plant-Microbe Interactions. 29(3): 165-169.

　　6. Fei, Q., Li, P., Teng, C., B.C. Meyers†. (2015) Secondary siRNAs from Medicago NB-LRRs modulated via miRNA-target interactions and their abundances. The Plant Journal. 83(3): 451-65.

　　7. Fei, Q., Xia, R., and B.C. Meyers†. (2013) Phased, secondary, small interfering RNAs in posttranscriptional regulatory networks. The Plant Cell. 25(7): 2400–2415.

　　8. Xu, H., Dzhashiashvili, Y., Shah, A., Kunjamma, R.B., Weng, Y.L., Elbaz, B., Fei, Q., Jones, J.S., Li, Y.I., Zhuang, X., Ming, G.L., He, C., and B. Popko†. (2020) m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination. Neuron. 105(2):293-309.e5.

　　9. Hsu, P.J., Fei, Q., Dai, Q., Shi, H., Dominissini, D., Ma, L., and C. He†. (2019) Single base resolution mapping of 2’-O-methylation sites in human RNA and in 3’ terminal ends of small RNAs. Methods. pii: S1046-2023(18)30194-4.

　　10.Wei, J., Liu, F., Lu, Z., Fei, Q., Ai, Y., He, P.C., Shi, H., Cui, X., Su. R., Klungland, A., Jia, G., Chen, J., and C. He†. (2018) Differential m6A, m6Am, and m1A demethylation mediated by FTO in the cell nucleus and cytoplasm. Molecular Cell. 71(6):973-985.

　　11.Liu, H., Soyars, C., Li, J., Fei, Q., He, G., Peterson, B., Meyers, B.C., Nimchuk, Z.L., and X. Wang†. (2018) CRISPR/Cas9‐mediated resistance to cauliflower mosaic virus. Plant Direct. 2 (3), e00047.

　　12.Shu, X., Dai, Q., Wu, T., Bothwell, I.R., Yue, Y., Zhang, Z., Cao, J., Fei, Q., Luo, M., He, C. †, and J. Liu†. (2017) N6-Allyladenosine: a new small molecule for RNA labeling identified by mutation assay. Journal of the American Chemical Society. 139(48):17213-17216.

　　13.Yang, L., Qian, X., Chen, M., Fei, Q., Meyers, B.C., Liang, W., and D. Zhang†. (2016) Regulatory role of a receptor-like kinase in specifying anther cell identity in rice. Plant Physiology. 171(3):2085-100.