The Synthetic Yeast Genome Project (Sc2.0) is the world’s first synthetic eukaryotic genome project that aims to create a novel, rationalized version of the genome of the yeast species Saccharomyces cerevisiae. We have a better understanding of how yeast genome works after synthesizing yeast genome.  Based on what we learned from Sc2.0, we are aiming to re-design a yeast genome with well-known regulatory elements and codon-optimized open reading frames.  By doing this, we could engineer a simpler yeast genome, which would allow us to explore the folding and stabilizing mechanisms of eukaryotic chromatin.