张艳聪课题组

张艳聪课题组

Zhang Yancong Lab

课题组长

张艳聪，研究员，博士生导师。北京师范大学博士、哈佛大学博士后、麻省理工学院-哈佛大学博德研究所（Broad Institute）研究科学家（Research Scientist）。在美留学七余年，师从哈佛大学国际知名微生组学和计算生物学家、“人类微生物组计划”领军人Curtis Huttenhower教授。长期从事微生物组学研究，擅长多组学数据整合、人工智能与计算生物学分析。近年来在Nature（独立一作）、Nature Biotechnology (独立一作&共同通讯)等国际权威期刊发表SCI论文20余篇。获武田-《自然》“科学创新奖”（Takeda Innovators in Science Award with Nature）、“哈佛医学院华人科学家杰出研究奖”、“中国农业科学院2025年度重大科学发现”等奖励。

工作经历

2025.02 - 至今        中国农业科学院深圳农业基因组研究所，研究员

2022.08 - 2025.01  麻省理工学院-哈佛大学博得研究所，研究科学家

2018.06 - 2022.08  哈佛大学，博士后

教育经历

2012.09 - 2017.06  北京师范大学生态学  理学博士    

2008.09 - 2012.06  天津师范大学计算机科学与技术  工学学士

团队研究方向

1.开发基于AI与多组学的分析工具，解析微生物及其产物功能

2.挖掘关键微生物产物，阐释其在宿主健康和食品营养等生态环境中的作用

3.解析菌群-宿主-饮食环境互作机制，探索基于微生物组的个性化膳食方案

研究进展

肠道菌群, 作为寄居在宿主消化道内的微生物复杂群落，包含数量庞大、种类繁多的微小生命体。但是，肠道微生物组如何影响人体健康，目前仍存在诸多未知，大量肠道微生物产物功能未知且体量庞大，亟需进一步深入研究。针对这个难点，团队开展了系列工作：

1）构建了鉴别微生物基因功能潜力分析平台MetaWIBELE，实现对新型基因功能效力的高效评估，揭示了炎症性肠病中大量未知功能的肠道微生物基因的潜在重要性（Nature 2022）；

2）开发了AI驱动的微生物群落新型基因功能预测工具FUGAsseM，突破了微生物群落基因“暗物质”功能预测的技术瓶颈（Nature Biotechnology, 2025）；

3）进而整合宏转录组、代谢组等多组学大数据，鉴定了肠道微生物基因及代谢产物在炎症性肠病中的功能活性 (Nature 2022；Nature Medicine 2023；Bioinformatics 2021)。上述工作为基于微生物组的健康维护和疾病治疗提供新的潜在候选靶点。

代表论文

1. 1. Yancong Zhang, Amrisha Bhosle, Sena Bae, Lauren J. McIver, Emma K. Accorsi, Kelsey N. Thompson, Cesar Arze, Ya Wang, Ayshwarya Subramanian, Damian R. Plichta, Ali Rahnavard, Afrah Shafquat, Ramnik J. Xavier, Hera Vlamakis, Wendy S. Garrett, Andy Krueger, Curtis Huttenhower*, Eric A. Franzosa*. Discovery of bioactive microbial gene products in inflammatory bowel disease. Nature, 2022, 606: 754-760.

2. 2. Yancong Zhang#, Amrisha Bhosle, Sena Bae, Kelly Eckenrode, Xueying Huang, Jingjing Tang, Danylo Lavrentovich, Lana Awad, Ji Hua, Ya Wang, Xochitl C. Morgan, Bin Li, Andy Krueger, Wendy S. Garrett, Eric A. Franzosa#, Curtis Huttenhower#. Predicting functions of uncharacterized gene products from microbial communities. Nature Biotechnology (2025).

3. 3. Yancong Zhang, Kelsey N. Thompson, Curtis Huttenhower, Eric A. Franzosa. Statistical approaches for differential expression analysis in metatranscriptomics. Bioinformatics, 2021, 37(Suppl_1): i34-i41.

4. 4. Yancong Zhang#, Kelsey N. Thompson#, Tobyn Branck, Yan Yan, Long H. Nguyen, Eric A. Franzosa*, Curtis Huttenhower*. Metatranscriptomics for the human microbiome and microbial community functional profiling. Annual Review of Biomedical Data Science, 2021, 4: 279-311.

5. 5. Donggi Paik#, Lina Yao#, Yancong Zhang, Sena Bae, Gabriel D. D’Agostino, Minghao Zhang, Eunha Kim, Eric A. Franzosa, Julian Avila-Pacheco, Jordan E. Bisanz, Christopher K. Rakowski, Hera Vlamakis, Ramnik J. Xavier, Peter J. Turnbaugh, Randy S. Longman, Michael R. Krout, Clary B. Clish, Fraydoon Rastinejad, Curtis Huttenhower, Jun R. Huh*, A. Sloan Devlin*. Human gut bacteria produce TH17-modulating bile acid metabolites. Nature, 2022, 603: 907–912.

6. 6. Raaj S. Mehta#, Jared R. Mayers#, Yancong Zhang, Amrisha Bhosle, Nathaniel R. Glasser, Long H. Nguyen, Wenjie Ma, Sena Bae, Tobyn Branck, Kijun Song, Luke Sebastian, Julian Avila Pacheco, Hyuk-Soo Seo, Clary Clish, Sirano Dhe-Paganon, Ashwin N. Ananthakrishnan, Eric A. Franzosa, Emily P. Balskus*, Andrew T. Chan*, Curtis Huttenhower*. Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease. Nature Medicine, 2023, 29.3: 700-709.

7. 7. Amrisha Bhosle, Sena Bae, Yancong Zhang, Eunyoung Chun, Julian Avila-Pacheco, Ludwig Geistlinger, Gleb Pishchany, Jonathan N Glickman, Monia Michaud, Levi Waldron, Clary B Clish, Ramnik J Xavier, Hera Vlamakis, Eric A Franzosa*, Wendy S Garrett*, and Curtis Huttenhower*. Integrated annotation prioritizes metabolites with bioactivity in inflammatory bowel disease. Molecular Systems Biology, 2024, 0: 1-24.

8. 8. Sun-Yang Park, Chitong Rao, Katharine Z. Coyte, Gavin A. Kuziel, Yancong Zhang, Wentao Huang, Eric A. Franzosa, Jing-Ke Weng, Curtis Huttenhower, Seth Rakoff-Nahoum. Strain-level fitness in the gut microbiome is an emergent property of glycans and a single metabolite. Cell, 2022, 185.3: 513-529.

9. 9. Wei Li*, Saiyu Hang*, Yuan Fang, Sena Bae, Yancong Zhang, Minghao Zhang, Gang Wang, Megan D. McCurry, Munhyung Bae, Donggi Paik, Eric A. Franzosa, Fraydoon Rastinejad, Curtis Huttenhower, Lina Yao#, A. Sloan Devlin#, Jun R. Huh#. A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1. Cell Host & Microbe, 2021, 29.9: 1366-1377.

10. 10. Lina Yao*, Gabriel D. D'Agostino*, Jinseok Park*, Saiyu Hang, Arijit A. Adhikari, Yancong Zhang, Wei Li, Julian Avila-Pacheco, Sena Bae, Clary B. Clish, Eric A. Franzosa, Curtis Huttenhower, Jun R. Huh, A. Sloan Devlin. A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria. Nature Microbiology (2022) 7: 1404-1418.

张艳聪课题组更新于2026年2月