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梁翔禹课题组

梁翔禹.png

姓名:

梁翔禹

职称:

研究员,博士生导师,中国农科院“青年英才”

电话/传真:

13162916069

电子邮件:

liangxiangyu@caas.cn

实验室主页:

https://www.x-mol.com/groups/liangxiangyu

研究方向:

基于自然生物的构效关系,开发高性能仿生结构材料


 简历介绍:


梁翔禹,研究员,博士生导师,中国农科院青年英才


2019年博士毕业于复旦大学高分子科学系和聚合物分子工程国家重点实验室,先后在南方科技大学依次从事博士后和高级研究学者。长期专注于可降解生物材料、仿生材料设计与制造、组织工程和软材料极端力学等领域。现主持广东省自然科学基金(青年项目)和深圳市科技创新人才培养项目(博士启动)等。近年来共发表20余篇论文和3项中国发明专利,主要发表在Nature communication、Advanced materials、Advanced Functional Materials、Small、Biofabrication、Materials Chemistry Frontiers、ACS Biomaterials Science & Engineering等国际权威期刊上,其中以第一/通讯作者(含共同)在国际学术期刊上发表学术论文9篇。现为广东省自然科学基金项目入库评审专家。



 研究领域


研究内容:

受大自然的启发,人类已经开发了多种类型和多种功能的仿生材料(Bioinspired materials)。特别是具有独特且矛盾性质的多层分级结构的进化发展,例如高强度和韧性组合的,为现代先进材料工程提供了巨大的灵感。在合成复合材料中模仿自然的分级微观结构可以产生更耐损伤的结构,并且一些生物灵感材料已经在各种应用中实现。我们的研究方向主要是基于自然生物的构效关系,开发高性能仿生结构材料及其先进工艺技术,主要包括:第一,可降解生物材料;第二,仿生材料结构设计与制造;第三,组织工程与药物缓释。


研究进展:

课题组以天然高分子和可降解合成高分子为主要研究材料,利用3D打印、冷冻铸造、高分子成型与加工等方法,并结合计算机仿真等手段,来研究仿生材料的结构性能,特别是生物材料的降解特性、力学性能以及极端场景下的应用。课题组的研究方向主要包括:第一,可降解生物材料的开发与应用,如可降解塑料、可降解医用器械和可降解功能性器件等;第二,通过仿生设计材料的微观结构和化学组分,实现其在极端场景下的应用,如柔性电子器件、软体机器人和防护器具等;第三,通过对生物医用材料的结构形态和理化特性调控,开发出可软硬组织修复与再生的多孔聚合物支架材料。


 代表论著:


代表论文

(# Equal contribution; * Corresponding author)

1. Xiangyu Liang, Guangda Chen, Iek Man Lei, Pei Zhang, Zeyu Wang, Xingmei Chen, Mengze Lu, Jiajun Zhang, Zongbao Wang, Taolin Sun, Yang Lan and J. Liu*. Impact-Resistant Hydrogels by Harnessing 2D Hierarchical Structures. Advanced Materials, 2022, 2207587. (Cover paper)

2. Xiangyu Liang, Guangda Chen, Shaoting Lin, Jiajun Zhang, Liu Wang, Pei Zhang, Yang Lan, Ji Liu*. Bioinspired 2D Isotropically Fatigue-Resistant Hydrogels. Advanced Materials, 2022, 34, 2107106. (Cover paper).

3. Xiangyu Liang, Guangda Chen, Shaoting Lin, Jiajun Zhang, Liu Wang, Pei Zhang, Zeyu Wang, Zongbao Wang, Yang Lan, Qi Ge, Ji Liu*. Anisotropically Fatigue-Resistant Hydrogels. Advanced Materials, 2021, 33, 2102011.

4. Guangda Chen# , Xiangyu Liang#, Pei Zhang, Shaoting Lin, Ziyi Yu and Ji Liu, Bioinspired 3D Printing of Functional Materials by Harnessing Enzyme-Induced Biomineralization. Advanced Functional Materials, 2022, 32, 2113262. (Co-first author, Cover paper)

5. Xiangyu Liang, Jingming Gao, Weike Xu, Xiuli Wang, Yang Shen, Jingyu Tang, Shuquan Cui, Xiaowei Yang, Qingsong Liu, Lin Yu, Jiandong Ding*. Structural Mechanics of 3D-printed Poly(lactic acid) Scaffolds with Tetragonal, Hexagonal and Wheel-like Designs. Biofabrication, 2019, 11, 035009.

6. Xiangyu Liang, Yongli Qi, Zhen Pan, Yao He, Xiangnan Liu, Shuquan Cui, Jiandong Ding*. Design and Preparation of Quasi-spherical Salt Particles as Water-soluble Porogens to Fabricate Hydrophobic Porous Scaffolds for Tissue Engineering and Tissue Regeneration. Materials Chemistry Frontiers, 2018, 2, 1539-1553.

7. Xiangyu Liang#, Pingguo Duan#, Jingming Gao, Runsheng Guo, Zehua Qu, Xiaofeng Li, Yao He, Haoqun Yao, Jiandong Ding*. Bilayered PLGA/PLGA-HAp Composite Scaffold for Osteochondral Tissue Engineering and Tissue Regeneration. ACS Biomaterials Science & Engineering, 2018, 4, 3506-3521.

8. Xiangyu Liang, Junjie Wen, Caihong Wen, Bo Wang, Jianyu Chen, Li Zhou*. Preparation of O-hydroxypropyl-N-butyl Chitosan under Microwave Irradiation. Journal of Applied Polymer Science. 2015, 132, 41527.

9. Yue Tao,# Xiangyu Liang,# Jun Zhang, Iek Man Lei, Ji Liu*. Polyurethane Vitrimers: Chemistry, Properties and Applications. Journal of Polymer Science, 2022, 1-21. DOI: 10.1002/pol.20220625. (Co-first author)

10. Pei Zhang, Iek Man Lei, Guangda Chen, Jingsen Lin, Xingmei Chen, Jiajun Zhang, Chengcheng Cai, Xiangyu Liang and J. Liu*. Integrated 3D Printing of Flexible Electroluminescent Devices and Soft Robots, Nature Communication, 2022, 13, 4775. (Cover paper)

11. Jiajun Zhang,# Lulu Wang,# Yu Xue,# Iek Man Lei, Xingmei Chen, Pei Zhang, Chengcheng Cai, Xiangyu Liang, Yi Lu, Ji Liu*.Engineering Electrodes with Robust Conducting Hydrogel Coating for Neural Recording and Modulation, Advanced Materials, 2022, 35(3), 202209324. (Cover paper)

12. Kuan Zhang,# Xingmei Chen,# Yu Xue,# Jingsen Lin, Xiangyu Liang, Jiajun Zhang, Jun Zhang, Guangda Chen, Chengcheng Cai, Ji Liu*. Tough Hydrogel Bioadhesives for Sutureless Wound Sealing, Hemostasis and Biointerfaces, Advanced Functional Materials, 2022, 32(15), 2111465.

13. Xingmei Chen, Jun Zhang, Guangda Chen, Yu Xue, JiaJun Zhang, Xiangyu Liang, Iek Man Lei, Jingsen Lin, Ben Xu, Ji Liu*. Hydrogel Bioadhesives with Extreme Acid-Tolerance for Gastric Perforation Repairing. Advanced Functional Materials, 2022, 32, 2202285. (Cover paper)

14. Jun Zhang,# Yaya Wang,# JiaJun Zhang, Iek Man Lei, Guangda Chen, Yu Xue, Xiangyu Liang, Daozeng Wang, Guigen Wang, Sisi He,* Ji Liu*. Robust Hydrogel Adhesion by Harnessing Bioinspired Interfacial Mineralization. Small, 2022, 18, 202201796.

15. Xiang Yao, Ruili Liu, Xiangyu Liang, Jiandong Ding*. Critical Areas of Proliferation of Single Cells on Micropatterned Surfaces and Corresponding Cell Type Dependence. ACS Applied Materials & Interfaces, 2019, 11(17): 15366-15380.


代表专利:

1. 丁建东,梁翔禹,高镜铭,一种车轮状多孔支架及其制备方法与应用,中国发明专利,2019NO201910116354.5。(已授权)

2. 刘吉,梁翔禹,张加俊,陈广大,一种抗疲劳水凝胶的制备方法及其应用,中国发明专利,2021NO: 202110106029.8。(已授权)

3. 刘吉,陈广大,梁翔禹,一种矿化水凝胶的制备方法及其应用,中国发明专利,2021NO202111047086.X。(审查中)


梁翔禹课题组更新于2023年9月

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