张江课题组

联系方式：zhangjiang@caas.cn

所属中心：生态基因组研究中心

所属团队：农业有害生物基因组学创新团队

简介

张江，研究员，博士生导师，中心主任。

2008年获得中科院上海植物生理生态研究所博士学位，2008-2015年在德国马普分子植物生理所从事博士后研究。课题组长期从事植物质体工程与抗虫生物技术研究，近年来针对我国重大农林害虫，建立起了一套基于质体介导RNAi抗虫的技术体系，为我国RNA生物农药的研制与开发奠定了基础。先后主持国家自然科学基金，国家重点研发计划课题、德国马普伙伴小组等项目。以第一作者或通讯作者身份在Science, PNAS, Molecular Plant, Microbiome, New Phytologist, Trends in Biotechnology, Plant Biotechnology Journal, Journal of Integrative Plant Biology, Plant Cell & Environment，Plant Journal等杂志上发表高水平论文58篇，论文累计影响因子532.2。授权发明专利11项。

研究方向

1. 影响质体介导RNAi抗虫效率的主要因子及其调控机制；

2. 重大作物RNAi抗虫育种；

3. RNAi防控鳞翅目害虫的效率提升；

4. 害虫RNAi抗性发生的分子机制及抗性治理；

研究进展

1.系统解析了肠道核酸酶和微生物等因子影响不同种类害虫差异化响应RNAi的分子机制；

2.首次建立了基于植物质体和病毒样颗粒的RNAi分子高效递送系统；

3.建立了基于肠道菌群干扰等技术的RNAi协同增效技术与应用；

主要代表性论著

1. Mengting Wu, Yi Dong, Qi Zhang, Shengchun Li, Ling Chang, F. Vanessa Loiacono, Stephanie Ruf, Jiang Zhang*, Ralph Bock*. (2022) Efficient control of western flower thrips by plastid-mediated RNA interference. Proceedings of the National Academy of Sciences of the United States of America. 119(15):e2120081119.

2. Zhang J, Khan SA, Hasse C, Ruf S, Heckel DG, Bock R (2015) Pest control. Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids. Science 347: 991-994

3. Yong Wang, Mengnan Wang, Yali Zhang, Longwei Peng, Dadong Dai, Fengjuan Zhang*, Jiang Zhang* (2024) Efficient control of root-knot nematode by expressing Bt nematicidal protein in root leucoplasts. Molecular Plant 17(10):1504-1519.

4. Jiang C, Fu J, Xia K, Li S, Chang L, Bock R, Zhang J. (2024) Plastid engineering with an efficient RNAi delivery system based on bacteriophage MS2 virus-like particles enhances resistance to cotton bollworm.（2024） Molecular Plant 17(7): 987-989.

5. Dong Y, Wu M, Zhang Q, Fu J, Loiacono FV, Yang Y, Wang Z, Li S, Chang L, Bock R, Zhang J. (2022) Control of a sap-sucking insect pest by plastid-mediated RNA interference. Molecular Plant 15(7): 1176-1191.

6. Haitao Wang#, Fengjuan Zhang#, Yali Zhang, Mengnan Wang, Yiqiu Zhang, Jiang Zhang* (2024) Enrichment of novel entomopathogenic Pseudomonas species enhances willow resistance to leaf beetles. Microbiome 12:169.

7. Xu L, Xu S, Sun L, Zhang Y, Luo J, Bock R, Zhang J. (2021) Synergistic action of the gut microbiota in environmental RNA interference in a leaf beetle. Microbiome 9: 98.

8. Yi Dong^#, Qi Zhang^#, Yaruo Mao, Mengting Wu, Zican Wang, Ling Chang*, Jiang Zhang* (2024) Control of two insect pests by expression of a mismatch corrected double-stranded RNA in plants. Plant Biotechnology Journal 22(7):2010-2019.

9. Xu W, Li S, Bock R, Zhang J. (2024) A heat-inducible expression system for external control of gene expression in plastids. Plant Biotechnology Journal 22(4): 960-969.

10. Fu J, Zhang J* (2026) Editing and synthetic applications of chloroplast genomes. Plant Communications 7: 101783.

11. Zhang Y, Ke Z, Xu L, Yang Y, Chang L, Zhang J. (2024) A faster killing effect of plastid-mediated RNA interference on a leaf beetle through induced dysbiosis of the gut bacteria. Plant Communications 5(9): 100974.

12. Huang Y, Huang J, Kim D. S., Zhang J. (2025) The essential role of gut microbiota in dsRNA-mediated pest control of the phytophagous ladybird beetle, Henosepilachna vigintioctopunctata. npj Bioblims & Microbiomes 11(1): 141. 

13. Mengnan Wang^#, Yong Wang^#, Fengjuan Zhang, Jinqiu Fu*, Jiang Zhang* (2026) Functional RNA interference screening of chitin metabolism genes for targeted control of the willow leaf beetle. Entomologia Generalis.

14. Jiang C, Xiong D, Li F, Huang X, Li S, Zhang J, Chang L. (2025) Virus-like particles empower RNAi for effective control of a Coleopteran pest. Entomologia Generalis 45: 1147–1158.

15. Liao J, He H, Liu X, Chang L, Zhang J. (2025) Transplastomic RNAi potato plants targeting potato ladybird: No adverse effects on non-target pests or their natural enemies. Entomologia Generalis 45: 869–877.

16. Wu M, Zhang Q, Dong Y, Wang Z, Zhan W, Ke Z, Li S, He L, Ruf S, Bock R, Zhang J. (2023) Transplastomic tomatoes expressing double-stranded RNA against a conserved gene are efficiently protected from multiple spider mites. New Phytologist 237(4): 1363-1373.

主要承担项目

1.国家重点研发计划（2025YFA0921502）：叶绿体基因组结构优化，2029.11-2029.10，主持，在研

2.国家重点研发计划（2023YFC2607000）:基于RNAi的农业有害入侵物种精准控制技术研究，2023.11-2025.10，参与，结题

3.国家自然科学基金面上项目（32271912）：假单胞菌协同杨树质体介导RNAi抗虫的机制研究，2023.1-2026.12，主持，在研

4.国家自然科学基金面上项目（31872035）：棉铃虫对质体介导RNAi不应性的分子机制与治理策略研究，2019.1-2022.12，主持，结题

5.国家重点研发计划 （2017YFD0600101）：子课题-- RNAi介导抗虫技术在防治森林害虫中的应用；2017.1-2021.6, 主持，结题

6.国家自然科学基金面上项目（31572071）：双链RNA在转化质体中表达稳定性的探讨及其杀虫功能性研究，2016.1-2019.12，主持，结题

张江课题组更新于2026年7月23日