萧玉涛课题组

	姓名：		萧玉涛
	职称：		研究员，博士生导师
	电话/传真：		0755-84235795
	电子邮件：		xiaoyutao@caas.cn
	实验室主页：
	研究方向：		重要本土和入侵农业害虫适应性进化机制

 简历介绍：

萧玉涛，研究员，博士生导师。

现担任中国农业科学院农业基因组研究所“农业昆虫基因组学”创新团队首席科学家，长期从事农业昆虫与害虫防治研究工作，围绕草地贪夜蛾、棉铃虫等重要农业害虫，综合运用多组学手段和基因编辑等分子生物学技术，在农业害虫适应性进化机制研究方面取得了一系列重要成果。先后主持国家自然科学基金青年基金和面上项目、转基因新品种培育重大专项子课题、科技创新2030重大项目课题、深圳市科创委基础研究重点项目等16项；以通讯作者在The Innovation、PNAS、Molecular Biology and Evolution、Molecular Ecology Resources、Molecular Ecology、BMC biology、IBMB、PMS等期刊发表多篇SCI论文，中文文章8篇；授权国家发明专利6项；参加国际学术会议并作报告7次。

 课题组成员：

PI: 萧玉涛（xiaoyutao@caas.cn）

兼职教授：David Goodwin Heckel（heckel@ice.mpg.de）

副研究员：靳明辉（jinminghui@caas.cn），张磊（zhanglei02@caas.cn），徐琦（xuqi@caas.cn）。

科研助理：吴超（wuchao@caas.cn），黄嘉琦（huangjiaqi01@caas.cn）。

博士后：刘振兴 (liuzhenxing@caas.cn)，李洪冉（lihongran@caas.cn），王鹏 （wangpeng01@caas.cn），朱经云（zhujingyun@caas.cn），邹路明（zouluming@caas.cn），范文敏（fanwenmg@163.com），史学涛（shixuetao@caas.cn）

博士生：梁馨月（1824926569@qq.com），单银雪（1805024712@qq.com），彭炎（1300538321@qq.com），龙广燕（1210328883@qq.com）。

硕士生：王平（wangping2755@163.com），何艳瑾（2694264377@qq.com），张竹亭（zzting6650@163.com），刘学峰（1668001561@qq.com），彭捷（1508542130@qq.com），刘壮壮（2302516512@qq.com），王娜（2765389182@qq.com），刘欣烨（liuxinye408@163.com），平君芬（pjfshengwu@163.com），赵崇君（754004404@qq.com），Alexander Englem Yesaya（alexanderyesaya19@gmail.com），VIGAN Chess-Kadouste（vigankadouste@yahoo.com）。

 研究领域：

研究方向：

农业害虫适应性进化是其暴发成灾的根本原因。课题组以农业领域重要本土和入侵性害虫棉铃虫、草地贪夜蛾、小地老虎等为研究对象，综合运用群体基因组学、关联分析、基因编辑、细胞生物学、生物测定等方法，解析害虫的环境适应性进化机制（抗药性、Bt抗性、耐寒性等），鉴定致害性新基因或位点，挖掘害虫防控新靶标，应用于害虫绿色防控新技术和新措施研发。

研究进展：

1）重大农业害虫基因组图谱绘制：结合PacBio、Nanopore、Hi-C等技术完成草地贪夜蛾等害虫的高质量基因组图谱，揭示了入侵我国的草地贪夜蛾以“玉米型”遗传背景为主导并明确其群体抗药性特征。相关研究成果发表在MER、BMC biology等期刊。

2）害虫农药及Bt抗性分子机制：首次阐释害虫通过Cad、ABCC2、ABCC3、ABCB6等基因多种类型变异介导的抗药性机理，成功解析害虫对Bt、农药、棉酚等杀虫物质产生抗性和交互抗性的新机制。相关研究成果发表在Ecology letters、 eLife、Plos pathogens、AEM、IBMB、PMS等昆虫学TOP期刊。

3）重大农业害虫适应性进化机制：综合运用基因组学、种群遗传学等技术，揭示重大农业害虫棉铃虫和亚州玉米螟环境适应性进化机制，相关研究成果发表在The Innovation、Molecular Biology and Evolution等期刊。

 代表论著：

代表论文：

1. Minghui Jin#; Yinxue Shan#; Yan Peng#; Wenhui Wang#; Huihui Zhang; Kaiyu Liu; David G. Heckel; Kongming Wu*; Bruce E. Tabashnik; Yutao Xiao*. Downregulation of a transcription factor associated with resistance to Bt toxin Vip3Aa in the invasive fall armyworm. Proceedings of the National Academy of Sciences of the United States of America, 2023, 140(44): e2306932120.

2. Minghui Jin#; Yan Peng#; Jie Peng#; Huihui Zhang; Yinxue Shan; Kaiyu Liu; Yutao Xiao*. Transcriptional regulation and overexpression of GST cluster enhances pesticide resistance in the cotton bollworm, Helicoverpa armigera (Lepidoptera: Noctuidae). Communications Biology, 2023, 6: 1064.

3. Xinyue Liang; Ping Wang; Lei Zhang; Zaiyuan Li; Yutao Xiao*. Determining the complete mitochondrial genome of Tethea albicostata (Lepidoptera: Drepanidae) and phylogenetic analysis. Mitochondrial DNA Part B-Resources, 2023, 8(9): 963-966.

4. Lei Zhang#, Zaiyuan Li#, Yan Peng#, Xinyue Liang, Kenneth Wilson, Gilson Chipabika, Patrick Karangwa, Bellancile Uzayisenga, Benjamin A. Mensah, Donald L. Kachigamba, Yutao Xiao*. Global genomic signature reveals the evolution of fall armyworm in the Eastern hemisphere. Molecular Ecology, 2023, 00, 1-16.

5. Kaikai Mao, Hongran Li, Jingyun Zhu, Minghui Jin, Peng Wang, Yan Peng, Yutao Xiao*. Rapid test to detect insecticide resistance in field populations of Spodoptera frugiperda (Lepidoptera: Noctuidae). Frontiers in Physiology, 2023, 14:1254765.

6. Minghui Jin#, Yinxue Shan#, Qi Li, Yan Peng, Yutao Xiao*. A novel Cry1A resistance allele of fall armyworm in the new invaded region. International Journal of Biological Macromolecules, 2023, 244: 125392.

7. Minghui Jin#, Henry L. North#, Yan Peng#, Hangwei Liu#, Bo Liu#, Ruiqing Pan#, Yan Zhou#, Weigang Zheng, Kaiyu Liu, Bo Yang, Lei Zhang, Qi Xu, Samia Elfekih, Wendy A. Valencia-Montoya, Tom Walsh, Peng Cui, Yongfeng Zhou, Kenneth Wilson, Chris Jiggins*, Kongming Wu*, Yutao Xiao*. Adaptive evolution to the natural and anthropogenic environment in a global invasive crop pest, the cotton bollworm. The Innovation, 2023, 4(4): 100454.

8. Ying Cheng#, Peng Wang#, Yuxiao Zeng, Wenwen An, Tao Wang, Yutao Xiao*. Characterization of five pigmentation genes as transgenic markers in Spodoptera frugiperda (Lepidoptera: Noctuidae). International Journal of Biological Macromolecules, 2023, 242(3): 124981.

9. Yan Peng#, Minghui Jin#, Zhimin Li#, Hongran Li#, Lei Zhang, Songmiao Yu, Zhuting Zhang, Ruyi Fan, Jimin Liu, Qi Xu, Kenneth Wilson, Yutao Xiao*. Population-genomics provide insights into the evolution and adaptation of the Asia corn borer. Molecular Biology and Evolution, 2023, 40(5): msad112.

10. Xinyue Liang, Lei Zhang, Zaiyuan Li, Yutao Xiao*. Characterization of the mitochondrial genome of the lawn cutworm Spodoptera depravata (Lepidoptera: Noctuidae). Mitochondrial DNA Part B-Resources, 2023, 8(2): 310-313.

11. Minghui Jin#, Bo Liu#, Weigang Zheng#, Conghui Liu#, Zhenxing Liu#, Yuan He#, Xiaokang Li, Chao Wu, Ping Wang, Kaiyu Liu, Shigang Wu, Hangwei Liu, Swapan Chakrabarty, Haibin Yuan, Kenneth Wilson, Kongming Wu*, Wei Fan*, Yutao Xiao*.Chromosome‑level genome of black cutworm provides novel insights into polyphagy and seasonal migration in insects. BMC Biology, 2023, 21(1):2.

12. He Yuan#, Bojia Gao#, Chao Wu#, Lei Zhang, Hui Li, Yutao Xiao*, Kongming Wu*. Genome of the hoverfly Eupeodes corollae provides insights into the evolution of predation and pollination in insects. BMC Biology, 2022, 20: 157.

13. Yinxue Shan#, Minghui Jin#, Swapan Chakrabarty#, Bo Yang, Qi Li, Ying Cheng, Lei Zhang *, Yutao Xiao*. Sf-FGFR and Sf-SR-C Are Not the Receptors for Vip3Aa to Exert Insecticidal Toxicity in Spodoptera frugiperda. Insects, 2022, 13(6): 547.

14. Chongyu Liao, Dandan Zhang, Ying Cheng, Yongbo Yang, Kaiyu Liu, Kongming Wu*, Yutao Xiao*. Down-regulation of HaABCC3, potentially mediated by a cis-regulatory mechanism, is involved in resistance to Cry1Ac in the cotton bollworm, Helicoverpa armigera. Insect science, 2022, 0, 1-11.

15. Chao Wu#, Lei Zhang#, Bo Liu#, Bojia Gao, Cong Huang, Ji Zhang, Minghui Jin, Hanyue Wang, Yan Peng, Annabel Rice, Esmat Hegazi, Kenneth Wilson*, Pengjun Xu*, Yutao Xiao*. Genomic features of the polyphagous cotton leafworm Spodoptera littoralis. BMC Genomics, 2022, 23(1): 353.

16. Chongyu Liao, Minghui Jin, Ying Cheng, Yongbo Yang, Mario Soberón, Alejandra Bravo, Kaiyu Liu*, Yutao Xiao*. Bacillus thuringiensis Cry1Ac Protoxin and Activated Toxin Exert Differential Toxicity Due to a Synergistic Interplay of Cadherin with ABCC Transporters in the Cotton Bollworm. Applied and environmental microbiology, 2022, 88(7): e02505-21.

17. Qi Li#, Minghui Jin#, Songmiao Yu, Ying Cheng, Yinxue Shan, Peng Wang, Haibin Yuan*, Yutao Xiao*.Knockout of the ABCB1 gene increases susceptibility to emamectin benzoate, beta-cypermethrin and chlorantraniliprole in Spodoptera frugiperda. Insects, 2022, 13(2): 137.

18. Minghui Jin#, Yinxue Shan#, Yan Peng#, Ping Wang, Qi Li, Songmiao Yu, Lei Zhang*, Yutao Xiao*. An Integrative Analysis of Transcriptomics and Proteomics Reveals Novel Insights into the Response in the Midgut of Spodoptera frugiperda Larvae to Vip3Aa. Toxins, 2022, 14(1): 55.

19. Dandan Zhang#, Minghui Jin#, Yanchao Yang, Jianfeng Zhang, Yongbo Yang, Kaiyu Liu,Mario Sober´on, Alejandra Bravo, Yutao Xiao*, Kongming Wu*. Synergistic resistance of Helicoverpa armigera to Bt toxins linked to cadherin and ABC transporters mutations. Insect Biochemistry and Molecular Biology, 2021, 137: e103635.

20. Zaiyuan Li, Wenkai Wang, Yutao Xiao*, Lei Zhang*. Characterization of the mitochondrial genome of Spodoptera exempta (Lepidoptera: Noctuidae) from South Africa. Mitochondrial DNA Part B, 2021, 6(2): 370-372.

21. Yutao Xiao#, Wenjing Li#, Xianming Yang#, Pengjun Xu#, Minghui Jin, He Yuan, Weigang Zheng, Mario Soberón, Alejandra Bravo, Kenneth Wilson, Kongming Wu*. Rapid spread of a densovirus in a major crop pest following wide-scale adoption of Bt-cotton in China. eLife, 2021, 10: e66913.

22. Liu Yuanyuan, Jin Minghui, Wang Ling, Wang Haixia, Xia Zhichao, Yang Yongbo, Bravo Alejandra, Soberon Mario, Xiao Yutao*, Liu Kaiyu*. SfABCC2 transporter extracellular loops 2 and 4 are responsible for the Cry1Fa insecticidal specificity against Spodoptera frugiperda. Insect Biochemistry and Molecular Biology, 2021, 135.

23. Jin Minghui, Tao Jiahui, Li Qi, Cheng Ying, Sun Xiaoxu, Wu Kongming, Xiao Yutao*. Genome editing of the SfABCC2 gene confers resistance to Cry1F toxin from Bacillus thuringiensis in Spodoptera frugiperda. Journal of Integrative Agriculture, 2021, 20(3): 815-820.

24. Minghui Jin, Yanchao Yang, Yinxue Shan, Swapan Chakrabarty, Ying Cheng , Mario Soberón, Alejandra Bravo, Kaiyu Liu, Kongming Wu*, Yutao Xiao*. Two ABC transporters are differentially involved in the toxicity of two Bacillus thuringiensis Cry1 toxins to the invasive crop-pest Spodoptera frugiperda (J. E. Smith). Pest Management Science, 2021, 77(3): 1492-1501.

25. Zhang Lei#, Liu Bo#, Zheng Weigang#, Liu Conghui#, Zhang Dandan#, Zhao Shengyuan#, Li Zaiyuan, Xu Pengjun, Wilson Kenneth, Withers Amy, Jones M. Christopher, Smith A. Judith, Chipabika Gilson, Kachigamba L.Donald, Nam Kiwoong, Alencon Emmanuelle d’, Liu Bei, Liang Xinyue, Jin Minghui, Wu Chao, Chakrabarty Swapan, Yang Xianming, Jiang Yuying, Liu Jie, Liu Xiaolin, Quan Weipeng, Wang Guirong, Fan Wei*, Qian Wanqiang*, Wu Kongming*, Xiao Yutao*. Genetic structure and insecticide resistance characteristics of fall armyworm populations invading China. Molecular Ecology Resources, 2020, 20(6): 1682-1696.

26. Jin Minghui#, Cheng Ying#, Guo Xueqin#, Li Meizhi, Chakrabarty Swapan, Liu Kaiyu, Wu Kongming, Xiao Yutao*. Down-regulation of lysosomal protein ABCB6 increases gossypol susceptibility in Helicoverpa armigera. Insect Biochemistry and Molecular Biology, 2020, 122: 103387.

27. Zhang Lei, Wu Chao, Xiao Yutao*. Preference Assessment of White-backed Planthopper Feeding on Rice. JoVE-Journal of Visualized Experiments, 2020, 159: e59323.

28. Chakrabarty Swapan, Jin Minghui, Wu Chao, Chakraborty Panchali, Xiao Yutao*. Bacillus thuringiensis vegetative insecticidal protein family Vip3A and mode of action against pest Lepidoptera. Pest Management Science, 2020, 76(5): 1612-1617.

29. Zhang Lihua#, Lu Guoqing#, Huang Xinzheng#, Guo Huiming, Su Xiaofeng, Han Lida, Zhang Yongjun, Qi Zhi, Xiao Yutao*, Cheng Hongmei*. Overexpression of the caryophyllene synthase gene GhTPS1 in cotton negatively affects multiple pests while attracting parasitoids. Pest Management Sciences, 2020, 76(5): 1722-1730.

30. Wu Chao, Chakrabarty Swapan, Jin Minghui, Liu Kaiyu*, Xiao Yutao*. Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity. International Journal of Molecular Sciences, 2019, 20(11): 2829.

31. Jin Minghui, Liao Chongyu, Fu Xingxian, Holdbrook Robert, Wu Kongming, Xiao Yutao*. Adaptive regulation of detoxification enzymes in Helicoverpa armigera to different host plants. Insect Molecular Biology, 2019, 28(5): 628-636.

32. Xiao Yutao, Wu kongming*. Recent progress on the interaction between insects and Bacillus thuringiensis crops. Philosophical Transactions of The Royal Society B: Biological Sciences, 2019, 374: 1767.

33. Jin Minghui, Liao Chongyu, Chakrabarty Swapan, Wu Kongming, Xiao Yutao*. Comparative Proteomics of Peritrophic Matrix Provides an Insight into its Role in Cry1Ac Resistance of Cotton Bollworm Helicoverpa armigera. Toxins, 2019, 11(2): 92.

34. Jin Minghui, Liao Chongyu, Chakrabarty Swapan, Zheng Weigang, Wu Kongming, Xiao Yutao*. Transcriptional response of ATP-binding cassette (ABC) transporters to insecticides in the cotton bollworm, Helicoverpa armigera. Pesticide Biochemistry and Physiology, 2019, 154: 46-59.

35. Han Yongqiang; Wu Chao; Yang Lang; Zhang Deyong; Xiao Yutao*. Resistance to Nilaparvata lugens in rice lines introgressed with the resistance genes Bph14 and Bph15 and related resistance types. PLoS ONE, 2018, 13(6): e0198630.

36. Huang Xinzheng# , Xiao Yutao# , KÖllner Tobias G., Jing Weixia, Kou Junfeng, Chen Jieyin, Liu Danfeng, Gu Shaohua, Wu Junxiang, Zhang Yongjun, Guo Yuyuan. The terpene synthase gene family in Gossypium hirsutum harbors a linalool synthase GhTPS12 implicated in direct defence responses against herbivores. Plant Cell & Environment, 2018, 41(1): 261-274.

37. Xiao Yutao, Dai Qing, Hu Ruqin, Pacheco Sabino, Yang Yongbo, Liang Gemei, Soberon Mario, Bravo Alejandra, Liu Kaiyu*, Wu Kongming*. A Single Point Mutation Resulting in Cadherin Mislocalization Underpins Resistance against Bacillus thuringiensis Toxin in Cotton Bollworm. Journal of Biological Chemistry, 2017, 292(7): 2933-2943.

38. Xiao Yutao#, Liu Kaiyu#, Zhang Dandan, Gong Lingling, He Fei, Soberoacuten Mario, Bravo Alejandra Bravo, Tabashnik Bruce E., Wu Kongming*. Resistance to Bacillus thuringiensis mediated by an ABC transporter mutation increases susceptibility to toxins from other bacteria in an invasive insect. PLoS Pathogens, 2016, 12(2): e1005450.

39. Xiao Yutao#, Wang Qi#, Erb Matthias, Turlings Ted C J, Ge Linquan, Hu Lingfei, Li Jiancai, Han Xiu, Zhang Tongfang, Lu Jing, Zhang Guren, Lou Yonggen*. Specific herbivore-induced volatiles defend plants and determine insect community composition in the field , Ecology Letters, 2012, 15(10): 1130-1139.

40. 张磊，梁馨月，张纪，萧玉涛. 基于线粒体全基因组解析华北地区棉铃虫种群遗传结构. 植物保护学报，2021，48(5)：964-969.

41. 程英，靳明辉，萧玉涛. 鳞翅目昆虫基因编辑技术研究进展. 生物技术通报，2020，36(03)：18-28.

42. 萧玉涛，吴超，吴孔明. 中国农业害虫防治科技70年的成就与展望. 应用昆虫学报，2019，56(06)：1115-1124.

43. 郑伟刚，靳明辉，Swapan Chakrabarty，肖彬，萧玉涛，袁海滨. 小地老虎不同组织表达差异揭示其翅发育机制. 生物技术通报，2019，35(10)：102-110.

44. 刘运泽，张丹丹，曲爱军，郑方强，萧玉涛.棉铃虫Bt抗感品系的转录组差异表达分析.山东农业科学，2019，51(07)：5-9.

45. 张磊，柳贝，姜玉英，刘杰，吴孔明，萧玉涛.中国不同地区草地贪夜蛾种群生物型分子特征分析. 植物保护，2019，45(04)：20-27.

46. 吴超，张磊，廖重宇，吴孔明，萧玉涛.草地贪夜蛾对化学农药和Bt作物的抗性机制及其治理技术研究进展. 植物保护学报，2019，46(03)：503-513.

47. 张磊，靳明辉，张丹丹，姜玉英，刘杰，吴孔明，萧玉涛. 入侵云南草地贪夜蛾的分子鉴定. 植物保护，2019，45(02)：19-24+56.

代表专利：

1. 萧玉涛，高博嘉，桃蛀螟抗菌肽、基因及其产品与应用，中国：ZL 2022104227428.

2. 萧玉涛，程英，曾宇笑，靳明辉，廖重宇，sfIMP-X1基因及其在草地贪夜蛾遗传防控中的应用，中国：ZL202110254411.3.

3. 萧玉涛，程英，曾宇笑，靳明辉，廖重宇，一种靶向草地贪夜蛾Doublesex基因雌性特异E3外显子的sgRNA及其应用，中国：ZL 202110055205X.

4. 靳明辉，萧玉涛，程英，廖重宇，CYP6AB9基因和干扰棉铃虫棉酚代谢的dsRNA及二者在防治棉铃虫中的应用，中国：ZL 201810424082.0.

5. 萧玉涛，靳明辉，程英，廖重宇，ABC转运蛋白作为靶点在防治害虫上的应用，中国：ZL 201810903918.5.

6. 靳明辉，萧玉涛，程英，廖重宇，一种棉铃虫CYP4L11基因的dsRNA及其应用，中国：ZL 201810385347.0.

7. 萧玉涛，张丹丹，胡朝兴，吴孔明，棉铃虫转运蛋白ABCC2及其编码基因和应用，中国：ZL201510309514.X.

萧玉涛课题组更新于2023年10月