Yuwen Liu

　　Yuwen Liu研究员

　　中国农业科学院深圳农业基因组研究所

　　深圳市大鹏新区鹏飞路7号 邮编：518124

　　Email: liuyuwen@caas.cn

　　出生时间：1984年10月31日

　　出生地点：湖北宜昌

 

　　学习经历

　　2006.9 - 2014.6      芝加哥大学         发育生物学                博士                

　　2002.9 - 2006.6      清华大学            生物科学与技术系      学士   

             

　　工作经历

　　2019.1至今                中国农业科学院深圳农业基因组研究所      研究员、博士生导师                           

　　2014.8 - 2018.7        芝加哥大学人类遗传系                              博士后 

　　

　　Yuwen Liu，研究员、博士生导师，广东省珠江人才青年拔尖人才，深圳市高层次人才。2006年于清华大学本科毕业，2014年在芝加哥大学取得博士学位。Yuwen Liu研究员在基因组和表观遗传学领域有着十多年的科学研究经历，长期专注于开发新的实验和计算方法，研究转录调控中的增强子定位和功能，以及非编码区 DNA 变异如何通过影响增强子功能而影响生物性状。截至2020年初，Yuwen Liu研究员共发表 11 篇 SCI 论文，Google Scholar总引用次数超过 670 次，其中以第一作者或并列第一作者在 Bioinformatics, Genome Biology, American Journal of Human Genetics, Journal of the American Chemical Society 等高水平杂志上共发表文章5 篇（累积影响因子 57.206），以共同作者在 Nature Genetics, Nature Communications 等高水平期刊发表 6 篇文章。引进农科院后，获得国家自然科学青年科学基金以及深圳科创委面上项目各 1 项。

 

　　部分论文†: 通讯作者

　　1. Liu Y#, Zhou J, White K P*. RNA-seq differential expression studies: more sequence or more replication?. Bioinformatics, 2013, 30(3): 301-304.

　　2. Liu Y#, Yu S#, Dhiman V K#, Tonya Brunetti, Heather Eckart*, Kevin P White*. Functional assessment of human enhancer activities using whole-genome STARR-sequencing. Genome biology, 2017, 18(1): 219.

　　3. Song Liu#, Yuwen Liu#, Qin Zhang, Jiayu Wu, Junbo Liang, Shan Yu, Gong-Hong Wei, Kevin P White*, Xiaoyue Wang*. Systematic identification of regulatory variants associated with cancer risk. Genome biology, 2017, 18(1): 194.

　　4. Lulu Hu#，Yuwen Liu#， Shengtong Han#，Lei Yang#，Xiaolong Cui，Yawei Gao，Qing Dai，Xingyu Lu，Xiaochen Kou，Yanhong Zhao，Wenhui Sheng，Shaorong Gao，Xin He*，Chuan He*. Jump-seq: Genome-Wide Capture and Amplification of 5Hydroxymethylcytosine Sites. Journal of the American Chemical Society, 2019.

　　5. Yuwen Liu#, Yanyu Liang, A Ercument Cicek, Zhongshan Li, Jinchen Li, Rebecca A Muhle, Martina Krenzer, Yue Mei, Yan Wang, Nicholas Knoblauch, Jean Morrison, Siming Zhao, Yi Jiang, Evan Geller, Iuliana Ionita-Laza, Jinyu Wu, Kun Xia, James P Noonan, Zhong Sheng Sun*, Xin He*. A statistical framework for mapping risk genes from de novo mutations in whole-genome-sequencing studies. The American Journal of Human Genetics, 2018, 102(6): 1031-1047.

　　6. Donna M Werling#, Harrison Brand, Joon-Yong An, Matthew R Stone, Lingxue Zhu, Joseph T Glessner, Ryan L Collins, Shan Dong, Ryan M Layer, Eirene Markenscoff-Papadimitriou, Andrew Farrell, Grace B Schwartz, Harold Z Wang, Benjamin B Currall, Xuefang Zhao, Jeanselle Dea, Clif Duhn, Carolyn A Erdman, Michael C Gilson, Rachita Yadav, Robert E Handsaker, Seva Kashin, Lambertus Klei, Jeffrey D Mandell, Tomasz J Nowakowski, Yuwen Liu, Sirisha Pochareddy, Louw Smith, Michael F Walker, Matthew J Waterman, Xin He, Arnold R Kriegstein, John L Rubenstein, Nenad Sestan, Steven A McCarroll, Benjamin M Neale, Hilary Coon, A Jeremy Willsey, Joseph D Buxbaum, Mark J Daly, Matthew W State, Aaron R Quinlan, Gabor T Marth, Kathryn Roeder, Bernie Devlin*, Michael E Talkowski*, Stephan J Sanders*. An analytical framework for whole-genome sequence association studies and its implications for autism spectrum disorder. Nature genetics, 2018, 50(5): 727.

　　7. Siming Zhao#, Jun Liu, Pranav Nanga, Yuwen Liu, A. Ercument Cicek, Nicholas Knoblauch, Chuan He, Matthew Stephens*，Xin He*. Detailed modeling of positive selection improves detection of cancer driver genes. Nature communications, 2019, 10(1): 3399.

　　8. Xinxin Ke#, Alesia Walker, Sven-Bastiaan Haange, Ilias Lagkouvardos, Yuwen Liu, Philippe Schmitt-Kopplin, Martinvon Bergen, Nico Jehmlich, Xin He, Thomas Clavel, Peter C.K. Cheung*. Synbiotic-driven improvement of metabolic disturbances is associated with changes in the gut microbiome in diet-induced obese mice. Molecular metabolism, 2019, 22: 96-109.

　　9.  Yingzheng Wang#, Mingjun Liu, Jiyang Zhang, Yuwen Liu, Megan Kopp, Weiwei Zheng, Shuo Xiao*. Multidrug resistance protein 1 deficiency promotes doxorubicin-induced ovarian toxicity in female mice. Toxicological Sciences, 2018, 163(1): 279-292.